【摘要】 目的 :研究骨组织提取的可溶性多肽片段药物“谷康泰灵”对大鼠骨折愈合的作用。方法 :80只SD大鼠右胫骨制成骨缺损后 ,肌注谷康泰灵 ,动态行骨折愈合质量的组织形态计量学、生物力学、X线照片和骨密度检查。结果 :早期骨小梁体积比 (TBV )高 2 4.7% ,成骨细胞表面积比 (OBS)高 2 6 .7% ;后期平均骨小梁愈合面积比 (MTHSR )高38.8% ;胫骨抗折能力强 0 .45 2 7～ 1.435 0N ;缺损胫骨骨密度高 7.6 5 % ;X线照片显示用药后骨缺损内骨小梁多 ,桥接骨缺损多。结论 :“谷康泰灵”能显著促进大鼠骨折愈合的速度和质量更多还原

【Abstract】 Objective: To study the effects of soluble multi-peptide agent,marked “Gu Kang Tai Ling”,derived from bone tissue on rat bone fracture healing.Methods 80 right tibia defects of rats were sawed.The “Gu Kang Tai Ling”were intramuscularly injected to the rats.The quality of the defect healing was investigated continuously and respectively by the defect bone histomorphometry,biomechanics,X-ray film,and bone mineral density(BMD).Results: Under the treatment of the agent,at early stage trabecular bone volume (TBV)ratio increased 24.7%,and osteoblast surface(OBS)26.7%,at late stage mean trabecular healing surface rate(MTHSR)was increased 38.8%,tibia anti-fracture strength 0.4527～1.4350N,and BMD 7.65% compared with the control group.Conclusion: “Gu Kang Tai Ling”can accelerate rat fracture healing and improve the quality of healing.更多还原