【摘要】 目的观察国产支架置入大冠状动脉后的生物、血液相容性、支架开通率及其内皮化情况。方法将１６个国产支架置入８只犬的冠状动脉内，分别于１、２、３、６个月进行观察。结果支架置入术后冠脉通畅，无明显狭窄。支架贴内膜良好，血管内腔表面光滑。术后２个月时支架覆盖的新生内膜最厚，其主要为平滑肌细胞和细胞外基质，未见明显炎性细胞浸润。支架置入１个月时，支架表面覆盖的内皮细胞排列不规则；置入２、３、６个月时，其沿血流方向排列规则。支架表面未见明显腐蚀。结论该国产支架置入后有良好的生物和血液相容性，理化性能稳定，迅速重新内皮化，有良好的开通率。更多还原

【Abstract】 Objective To investigate the biocompatibility, bloodcompatibility, the patency rates and reendothelialization of native coronary metallic stent after being implanted into canine coronary artery.Methods Sixteen stents were implanted into eight canine coronary artery through femoral artery aproach.The pathological examination was taken at 1 to 6 months after coronary angiography.Results Thirteen stents were successfully implanted into target vessels of six dogs. Two dogs died of coronary spasm and acute stent thrombosis respectively. Coronary angiography demonstrated all vessles patency after intracoronary stenting (ICS). Macroscopy of stented arteries demonstrated complete incorporation of stent wires into the arterial wall and smooth vessle lumens. Light microscope demonstrated the neointima was the thickest at two months and consisted mainly of smooth muscle cells and extracellular matrix. The findings also included slight to moderate media oppression localized to areas of stent wires and no significant inflammatory raction. Scanning electron mcroscope demonstrated the endotheliocytes covering on stents oriented irregularly at one month and regularly at two and three as well as six months in the direction of blood flow. There was no significant erosion on stent wires.Conclusion The native balloon- expandable coronary metallic stems are promisint with good biocompatibility, biocompatibility and physicochemical stability after being implanted into canine coronary arteries. They can maintain high patency rates due to rapid reendothelialization.更多还原