【摘要】 目的探讨经导管冠状动脉内无水酒精注射量及注射速度与心肌梗死面积的关系。方法用２０只小型猪，全部接受经导管心肌化学消融术，根据冠状动脉内无水酒精注射量、注射速度随机分为４组，每组５只。定量计算术后６小时相应心肌梗死面积，分别比较消融时无水酒精注射速度相同，但注入酒精量不同及消融时酒精注入量相同，但注射速度不同二组间心肌梗死面积。结果（１）以预设恒定酒精注射速度（０．２ ｍｌ／ｓ），注入酒精量 ２．０ｍｌ组相应心肌梗死面积（ｎ＝ ５）：（４．３±２．７）％，注入酒精量 ０．５ｍｌ组相应心肌梗死面积（ ｎ＝ ５）（ １０．１±４．６）％，两组比较心肌梗死面积不同（０．０２＜ Ｐ＜ ０．０５）。（２）以恒定酒精量注入，注射速度分别设为１．２ ｍｌ／ｓ及 ０．０６ｍｌ／ｓ两组心肌梗死面积分别为（７．１±１．６）％及（５．８±１．２）％，比较两组心肌梗死面积，无统计学差异（０．０５＜Ｐ＜０．２）。结论经导管心肌化学消融术中，心肌梗死面积大小与冠状动脉内无水酒精注入量有关，与冠状动脉内无水酒精注射速度无关。更多还原

【Abstract】 Objective To investigate the relationship between the volume, injection velocity and myocardial infarct size during myocardial ablation by catheter. Methods Twenty miniature pigs were all performed myocardial ablation by catheter and were at random equally divided into four groups (n = 5 in each) according to the volume and the injection velocity of intracoronary absolute alcohol. The myocardial infarct size was measured 6 hours after myocardial ablation and compared the myocardial infarct area between different groups with different volume of intracoronary absolute alcohol and compared the myocardial infarct size between different groups with different injection velocity. Results The myocardial infarct size in groups with different volume of intracoronary absolute alcohol (0.5ml and 2.0ml) are (4.3 ± 2.7)% and (10.1 ± 4.6)% respectively; The myocardial infarct size in groups with different injection velocity of intracoronary absolute alcohol (l.2 ml/s and 0.06ml/s) are (7.1 ± 1.6)% and (5.8± 1.2)% respectively; There were significant differences in myocardial infarct size with different volume of intracoronary absolute alcohol during myocardial ablation by catheter (0.02< P < 0.05) but no apparent differences were found in myocardial infarct size with different injection velocity of intracoronary absolute alcohol (0.05< P< 0.2). Conclusion The myocardial infarct size is in relation to the volume of intracoronary absolute alcohol during myocardial ablation by catheter, but have no relation to the injection velocity of intracoronary absolute alcohol.更多还原