【摘要】 目的　了解戊型病毒性肝炎在五型病毒性肝炎中的构成比及其临床特点。方法　应用ELISA法和PCR法对 1996～ 1998年诊治 3 3 8例病毒性肝炎病人进行了甲、乙、丙、丁、戊型肝炎病原体检测和临床特点的统计分析。结果　共检出戊型病毒性肝炎 3 2例 ,占受检人数的 8 2 %。其中单纯HEV、HEV +HAV、HEV +HBV、HEV +HAV +HBV、HEV +HCV感染率分别占 46 9%、18 8%、15 6%、9 4%、9 4%。临床分型主要是急性黄胆型 ,其次是急性无黄胆型及瘀胆型。戊型病毒性肝炎主要症状为 :纳差、厌油 (93 8% ) ,乏力 (81 3 % ) ,发热、头痛 (71 9% ) ,恶心、呕吐、黄胆 (5 9 4% ) ,肝肿大 (5 3 1% ) ,腹胀 (3 7 5 % ) ,可有心肌损害(12 5 % ) ,ALT几乎均有升高 (96 9% )。结论　HEV可单纯感染 ,也可与HAV、HBV、HCV混合感染 ,总混合感染率为 5 3 1% ,混合感染较单纯感染病情重、黄胆深 ,且病情恢复慢更多还原

【Abstract】 Objective To study on the constituent ratio of hepatitis E virus(HEV) in five types of viral hepatitis and its clinical characteristics.Methods The pathogen of HAV,HBV,HCV,HDV,HEV in 388 sera of patients with viral hepatitis was detected by ELISA and PCR from 1996 to 1998 and the data were analyzed statistically.Results The total infection rate of HEV was 8.2%(32/388).Among them,the infection rates of single HEV?HEV+HAV?HEV+HBV?HEV+HAV+HBV?HEV+HCV were 46.9%?18.8%?15.6%?9.4%?9.4%. The main clinical type was acute icterohepatitis on third stage and fourth stage and acute non-icterohepatitis and cholestatic hepatitis were followed as second main type.The main symptoms of virus hepatitis E were anorexia?oil weary(93.8%),acratia (81.3%),fever,headache(71.9%),nausea,vomitus,jaundice(59.4%),hepatomegaly(53.1%),abdominal distension(37.5%),cardiac muscle injury(12.5%),raise of ALT(96.9%).Conclusion The infection of HEV could be single or overlapping infection with HAV?HBV?HCV and the total overlapping infection rate was 53.1%. The situation of disease, the jaundice were both more serve and its situation recovered slower in single infection than in overlapping infection.更多还原