【摘要】 目的　观察伊维菌素驱治肠道线虫感染的效果及不良反应。　方法　采用单剂国产伊维菌素 12 mg、6 mg、12mg、12 mg(14岁以下儿童剂量减半 )分别治疗钩、蛔、鞭、蛲虫感染者 ,同时用阿苯达唑 40 0 mg治疗上述线虫感染者作为对照。　结果　伊维菌素和阿苯达唑对钩虫感染的虫卵阴转率分别为 5 8.0 0 % (2 9/ 5 0 )和 70 .5 9% (2 4/ 34) ;对蛔虫感染的虫卵阴转率分别为 10 0 % (5 1/ 5 1)和 97.0 6 % (33/ 34) ;对鞭虫感染的虫卵阴转率分别为 72 .0 0 % (36 / 5 0 )和 47.0 6 %(16 / 34) ;对蛲虫感染的虫卵阴转率分别为 5 6 .86 % (2 9/ 5 1)和 91.18% (31/ 34)。伊维菌素的不良反应发生率低而轻 ,对血象、肝肾功能和心电图无明显影响。　结论　伊维菌素 6 mg治疗蛔虫感染效果显著 ,12 mg治疗鞭虫感染效果优于阿苯达唑 40 0 mg,对钩虫和蛲虫感染亦有一定疗效 ,并且有排虫快、服药简便、不良反应少而轻等优点。更多还原

【Abstract】 Objective To observe the efficacy and side effect of ivermectin for treatment of intestinal nematode infections. Methods A single dose of ivermectin 12 mg, 6 mg, 12 mg, 12 mg(half dose by year under 14) was given to treat persons who were infected with hookworm, ascaris, whipworm and pinworm, and single dose of albendazole 400 mg was given to treat the persons who were infected with nematode as above as control. Results The hookworm, ascaris, whipworm and pinworm eggs negative conversion rates of ivermectin and albendazole were 58.0%(29/50) and 70.59%(24/34), 100.0%(51/51) and 97.06%(33/34), 72.00%(36/50) and 47.06%(16/34), 56.86%(29/51) and 91.18%(31/34). The side effect of ivermectin was mild and transient, and it had no adverse effect on blood picture, liver or renal function and ECG. Conclusion There was better effect against whipworm with ivermectin 12 mg than that with albendazole 400 mg, and the effect of ivermectin 6 mg on ascaris was as good as albendazole 400 mg, but not so good on hookworm and pinworm. The drug has characteristics of quick worm-expelling efficacy, convenience and seldom side effect.更多还原