【摘要】 目的　观察并比较脑胶质母细胞瘤放疗加化疗与不加化疗的疗效。方法　试验组 2 8例患者放射治疗 2 0～ 40Gy后 ,加用化疗药洛莫司汀 (CCNU)或卡莫司汀 (BCNU) ;对照组 2 8例单纯放射治疗 2 0～ 40Gy ,不加化疗药。结果　经随访 ,试验组和对照组 1,3,5年生存率分别为 5 7 1% ,2 2 5 % ,15 0 %和 17 9% ,7 1% ,3 6 % ,中位生存期分别为 2 9 7± 7 0个月和 9 7± 3 5个月 ,P <0 0 0 1,差异有极显著性。显示试验组疗效优于对照组。结论　脑瘤放疗 2 0～ 40Gy后 ,血脑屏障开放 ,是化疗最佳时机 ,这期间加化疗 ,可显著提高生存率。更多还原

【Abstract】 Objective To study the efficacy of chemotherapy for glioblastoma on the basis of brain irradiation. [WT5”HZ]Methods It was previously reported that the permeability of the blood brain barrier (BBB) to methotrexate could be increased by brain irradiation. In this study, glioblastoma patients were divided into 2 groups, 28 patients in each group. On group of patients was treated with CCNU or BCNU after having given 20～40 Gy irradiation to the brain. The other group of patients received radiation treatment alone. Results The 1, 3, and 5year survival rate of the two groups of patients was 57.1%, 22.5%, 15.0% and 17.9%, 7.1%, 3.6%, respectively. The median survival time was 29.7±7.0 and 9.7±3.5 months, respectively (P<0.001).[WT5”HZ]Conclusion Increase in permeability of the BBB after 20～40 Gy brain irradiation may provide an optimal chance for intracranial chemotherapy of glioblastoma.更多还原