【摘要】 目的　研究结核病控制三类不同干预措施对结核病病人疾病负担的影响。方法　采用WHO推荐的失能调整寿命年 (DALY)测算方法评价结核病病人的疾病负担。结果　例均初治TB病人 ,ITP地区为最轻 ,损失 0 31个DALY ;NTP地区居中 ,损失 0 42个DALY ;CTT地区为最重 ,损失 0 6 1个DALY ;例均复治TB病人 ,ITP为最轻 ,损失 0 6 2个DALY ;NTP居中 ,损失 0 5 9个DALY ;CTT为最重 ,损失0 91个DALY。从社会角度看 ,ITP地区每千人TB的DALY损失值年均为 16 42 ,NTP年均DALY损失值是 33 6 ,CTT年均DALY损失值是 37 36 ,NTP是ITP地区的 2 0 5倍 ,CTT是ITP的 2 2 8倍。结论　ITP在降低TB病人的疾病负担方面远胜于NTP与CTT ,不管从病人角度还是从社会角度 (社会发现率 ) ,其效果均较好更多还原

【Abstract】 Objective To study the effect of three different kinds of intervenient measures for TB control on the disease burden of TB patients. Method The estimating method of disability adjusted life years(DALY) as recommended by the WHO was used to assess the disease burden of TB patients. Result The average disease burden of new and retreated TB patients covered by the international TB program(ITP) was the lightest, with the loss of 0.31 DALY and 0.62 DALY respectively; the average disease burden of new and retreated TB patients covered by the national TB program(NTP) was intermediate, with the loss of 0.42 DALY and 0.59 DALY respectively; and the average disease burden of new and retreated TB patients from areas using conventional TB therapy(CTT) was the heaviest, with the loss of 0.61 DALY and 0.91 DALY respectively. From a social perspective, the average yearly loss of DALY per thousand TB patients in the ITP, NTP and CTT areas was respectively 16.42, 33.6 and 37.36, with the loss in the NTP areas being 2.05 times as much as that in the ITP areas and the loss in the CTT areas being 2.28 times as much as that in the NTP areas. Conclusion ITP was far superior to NTP and CTT in reducing the disease burden of TB patients, achieving better results both from the perspective of TB patients and the society.更多还原