【摘要】 目的　探讨阅读障碍儿童 (RD)在连续执行课题条件下 (CPT)事件相关电位 (ERP)特点和可能关联的神经学基础。方法　采用ERP技术结合语义、方向及音调辨别等CPT条件 ,对 16名RD男童及对照的正常男童进行测试 ,并就其准确率、反应时、误反应率、振幅和潜伏期等指标进行了比较分析。结果　在 3种辨别课题中 ,RD儿童和对照组儿童的音调辨别准确率、反应时、非视 高频刺激误反应率分别为 (6 5 4± 15 9) %和 (78 5± 12 6 ) %、(5 5 7 0± 97 8)ms和 (4 93 0± 47 8)ms、(1 1±0 7) %和 (0 6± 0 3) % ;而且方向和音调的ERP的P3 0 0 振幅降低 ,分别为 (2 0 8± 7 3) μV和 (2 7 7±8 3) μV、(9 1± 4 3) μV和 (14 6± 8 3) μV ;潜伏期延迟 ,音调潜伏期、语义认知处理性负相电位差别负波 (Nd)潜伏期、音调Nd潜伏期分别为 (5 71± 78)ms和 (5 12± 6 2 )ms、(398± 76 )ms和 (34 2± 6 7)ms、(373± 5 6 )ms和 (32 7± 5 3)ms。结论　RD儿童选择注意存在缺陷 ,提示与其额叶 基低神经节环路功能障碍相关。ERP附加CPT条件比单一靶标刺激更能反映RD儿童的认知特征更多还原

【Abstract】 Objective To investigate the characteristics of event related potential (ERP) of reading disabilities (RD) in children under the condition of continuous performance test (CPT) and their possible neurological basis. Methods Using ERP technique with CPT conditions, such as semantics, direction and pitch identification, 16 RD boys and their matched normal boys were tested A comparative study was conducted to analyze these indicators of accuracy, reaction time, false alarm, wave amplitude and latency between the two groups. Results Among the three kinds of identification tests, RD children had lower accuracy in pitch identification (65 4±15 9) to (78 5±12 6) and lower reaction speed (557.0±97 8) ms to (493.0±47 8) ms, as compared to the control group ( P <0 05) The false alarm rate was much higher in RD children than that in the control group with unattended high simulation (1 1±0 7)% to (0 6±0 3)%, P <0 05 Moreover, the P 300 amplitude decreased with direction of (20 8±7 3) to (27 7±8 3) μV and pitch of (9 1±4 3) to (14 6±8 3) μV, P <0 05 And, the latency delayed in pith of (571±78) ms to (512±62) ms,semantic cognition processing negativity Nd of (398±76) ms to (342±67) ms,pitch Nd of (373±56) ms to (327±53) ms, P <0 05. Conclusions There was defect in selective attention of RD children, which suggested relationship between dysfunction of frontal basal ganglia circle and RD The ERP combined with CPT was much better than that with single target stimulation to indicate children′s cognitive characteristics更多还原