【摘要】 目的　探讨低浓度混苯作业对女工月经周期生殖激素分泌的影响。方法　对 5 0名暴露组女工采用气相色谱法测定呼吸带空气中的苯、甲苯和二甲苯的浓度 ,对暴露组女工及外对照组和内对照组女工各 35名进行月经周期特征前瞻性调查 ,用酶免疫分析法测定尿液中的孕二醇 3 葡糖苷酸 (PdG)、雌酮结合物 (E1C)和卵泡刺激素 (FSH)。结果　空气中混苯以低浓度苯为主 ,苯检出率2 9 10 %、浓度 8 88(0 90～ 876 47)mg/m3 、超标率 2 1%、最大超标倍数 2 0 91倍 ;与内对照组和外对照组相比 ,低浓度混苯接触组女工黄体期长度缩短 ;与内对照组相比 ,暴露组的排卵前E1C水平、卵泡早期FSH水平以及卵泡早期和黄体期PdG水平明显降低。结论　低浓度混苯可以干扰接触女工下丘脑 垂体 卵巢轴中FSH、雌激素和孕激素的正常水平目的　探讨低浓度混苯作业对女工月经周期生殖激素分泌的影响。方法　对 5 0名暴露组女工采用气相色谱法测定呼吸带空气中的苯、甲苯和二甲苯的浓度 ,对暴露组女工及外对照组和内对照组女工各 35名进行月经周期特征前瞻性调查 ,用酶免疫分析法测定尿液中的孕二醇 3 葡糖苷酸 (PdG)、雌酮结合物 (E1C)和卵泡刺激素 (FSH)。结果　空气中混苯以低浓度苯为主 ,苯检出率2 9 10 %、浓度 8 88(0 90～ 876 4更多还原

【Abstract】 Objective To study the effects of exposure to low level of mixed benzene on reproductive hormone secretion during menstrual cycle in female workers. Methods Concentrations of benzene, toluene and xylene in the expiratory air of 50 exposed female workers from their breathing zone were determined with gas chromatography.Their menstrual cycles of 50 exposed workers and 35 internal control and 35 external control workers were studied prospectively. Urine pregnandiol 3 glucuronide (PdG), follicle stimulating hormone (FSH) and estrone conjugate (E 1C) were measured by enzyme immunoassay. Results Mixed benzene existed mainly in the form of low level benzene in the air of workplaces, with a detection rate of 29 10% at an average level of 8 88 (0 90 876 47) mg/m 3, and 21% of measurements exceeded the national maximum allowable concentration with the highest one as 20 91 folds high as that of the national hygienic standard. Length of luteal phase in the exposed group (13 7±1 5) days was significantly shorter than that in the internal and external control groups (14 5±1 2) days and (15 2±1 1) days ( P <0 05 or P <0 01). Urine level of E1C before ovulation, that of FSH at early follicular phase and that of PdG in luteal phase after ovulation in the exposed group were significantly lower than those in the internal control group ( P <0 05 or P <0 01 ). Conclusion Exposure to low level of mixed benzene in workspaces could interrupt the function of hypothalamic pituitary ovarian axis and affect their normal levels of FSH, PdG and E 1C更多还原