【摘要】 目的　探讨江苏省扬中市胃癌是否有地区和家庭聚集性。方法　利用扬中恶性肿瘤发病登记报告资料和全新设计的双Y核心家系调查资料 ,对 44 8个胃癌核心家系和 437个对照家系 ,共5 2 42人进行遗传流行病学研究。结果　Poisson分布 χ2 检验显示 ,胃癌在扬中市内各乡镇的实际分布与理论分布差异有显著性 ,χ2 =191 0 7,P <0 0 0 1,以三跃、长旺、油坊 3个乡发病率最高 ,与低发病率地区可相差 2 2倍 ;先证者同胞和父母胃癌患病率分别为 5 42 %和 8 6 5 % ,明显高于配偶同胞(3 2 0 % )和父母 (4 94% ) ;父母均患胃癌 ,其子女胃癌患病率最高为 2 2 5 8% ;二项分布检验显示 ,发生胃癌的观察家系数与理论家系数比较差异有极显著性。结论　扬中市胃癌高发不仅存在地区聚集性 ,而且有明显的家庭聚集性 ,初步认为符合多基因遗传方式 ,为探讨扬中市胃癌高发的遗传易感性因素和环境因素的差异提供了理论依据更多还原

【Abstract】 Objective To explore whether there existed spatial and familial aggregation in gastric cancer in Yangzhong City of Jiangsu Province Methods Using the data collected from cancer incidence registry and report system in Yangzhong City and newly designed investigation for double Y nuclear family, a genetic epidemiological study was conducted in 448 nuclear pedigrees with gastric cancer and 437 control pedigrees, involving 5 242 family members Results Chi square test of goodness of fit for Poisson distribution showed there was difference between real incidence rate of gastric cancer in all townships and towns in Yangzhong and expected distribution, with χ 2=191 07, P <0 001 The highest rate was in Sanyao, Changhong and Youfang townships, which was 2 2 times higher as that in the areas with low incidence rate Prevalence rate of gastric cancer was significantly higher in the siblings (5 42%) and parents (8 65%) of the probands, than that in siblings and parents of their spouses (4 94% and 3 20%, respectively) Prevalence rate of gastric cancer in the offspring with both parents suffered from gastric cancer was the highest, 22 58% Test for goodness of fit of binominal distribution showed that there was significant difference between observed number and expected number of pedigrees with gastric cancer, with P < 0 000 1 Conclusion There was not only significantly spatial aggregation of gastric cancer in Yangzhong City, but also familial aggregation, which coincided with a mode of multi genetic inheritance based on preliminary results and laid a foundation for exploring the difference in gentic susceptibilities and environmental factors for gastric cancer in Yangzhong City更多还原