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纤维连接蛋白及其整合素受体在视网膜前膜中的表达
Studies on the expression of fibronectin and integrins in epiretinal membranes
【摘要】 目的 研究增生性玻璃体视网膜病变 (proliferative vitreoretinopathy,PVR)的视网膜前膜(epiretinal membranes,ERM)中纤维连接蛋白 (fibronectin,FN)与整合素 β1 (β1 integrin,β1 )的表达。 方法 用免疫组织化学的方法对 2 0例 PVR患者行玻璃体切割术时剥离的 ERM进行观察。 结果 FN与β1分别在 18例及 16例 ERM中过度表达。 结论 ERM中有 FN及β1 的表达 ,提示二者在 PVR的发生发展中有一定作用。
【Abstract】 Objective To study the expression of the fibronectin (FN) and β 1 integrin (β 1) in epiretinal membranes(ERM) of eyes with proliferative vitreoretinopathy(PVR). Methods Twenty epiretinal membranes were obtained from eyes undergone vitrectomy for retinal detachment complicated with PVR and observed by immunohistochemical methods. Results Overexpression of FN and β 1 were observed in 18 and 16 membranes respectively. Conclusion The synergism of FN and β 1 in their action mignt be one of the important roles in the development of PVR.
【Key words】 Vitreoretinopathy,proliferative/physiopathology; Fibronectins; Antigens,CD 29; Immunohistochemistry;
- 【文献出处】 中华眼底病杂志 ,Chinese Journal of Ocular Fundus Diseases , 编辑部邮箱 ,2001年02期
- 【分类号】R774.1
- 【被引频次】2
- 【下载频次】45