【摘要】 济南目的　探讨移植心脏的冠状动脉硬化的发生和发展。方法　以供体脾细胞 (SPC)和环磷酰胺 (CP)预处理移植受体 ,诱导受体对移植物的免疫耐受。在移植术后的不同时间 ,取出移植心脏 ,行VanGieson染色 ,对移植心脏的冠状动脉硬化进行分析。结果　SPC和CP预处理后 ,移植心脏的存活时间明显延长 ,冠状动脉硬化明显减轻。结论　胶原纤维在血管壁内的广泛浸润 ,是引起冠状动脉向心性狭窄的主要原因之一 ;SPC和CP预处理 ,可以预防和减缓移植心脏动脉硬化的发生和发展更多还原

【Abstract】 Objective: To study the development of arteriosclerosis in rat cardiac allograft model. Methods: The recipient was pretreated with inoculation of donor spleen cells (SPC) followed by cyclophosphamide (CP) to induce donor specific cardiac allograft tolerance. The cardiac grafts were harvested at various stages after transplantation, and stained with Van Gieson of coronary arteriosclerosis. Results: Preconditioning with SPC and CP can prolong the cardiac allograft survival time. And coronary arteriosclerosis in cardiac allograft was significantly reduced. Conclusion: The infiltration of collagenous fiber in coronary arteries is one of the major cause of concentric stenosis. The pretreatment of SPC and CP can reduce the development of cardiac allograft arteriosclerosis.更多还原