【摘要】 目的观察系统性硬皮病 (PSS)患者循环内皮细胞（ CEC）数量的变化，了解 PSS患者的血管内皮细胞受损伤情况及川芎素对 PSS患者血管内皮细胞的影响，探讨川芎素治疗 PSS的疗效机理。方法使用川芎素治疗 PSS患者 38例，观察治疗前后 CEC的数量变化，以 53例健康人的 CEC数量作为对照比较。结果经川芎素治疗后， 38例 PSS患者的皮肤硬化、末梢疼痛、冷感、溃疡指数均有明显的改善（ P< 0.01）。治疗前 PSS患者的 CEC数量 (3.40± 1.27个 /0.9μ L)明显高于健康对照组 (1.13± 0.48个 /0.9μ L)，治疗后随着临床症状、体征的好转， CEC数量也显著下降 (1.80± 0.58个 /0.9μ L)。结论川芎素治疗 PSS不仅能显著改善临床症状和体征，而且对 PSS患者的血管内皮细胞损伤也有较好的治疗和保护作用。更多还原

【Abstract】 Objective To observe the quantity of circulating endothelial cells (CECs) in patients with progressive systemic sclerosis (PSS), and to investigate the effect of sodium ferulate (SF) on the vascular endothelial cell (VEC) of PSS patients. Methods 38 PSS patients were treated with SF, CEC of all patients were detected quantitatively before and after the treatment, and compared with that of 53 healthy controls. Results After the treatment with SF, the skin sclerosis, distal pain, cold sensation, and ulcer index in 38 PSS patients were improved (P< 0.01);the number of CEC also decreased, from 3.40± 0.27/0.9μ L before treatment which was markedly higher than that of normal controls (1.13± 0.48/0.9μ L) to 1.80± 0.58/0.9μ L after treatment. Conclusion SF can not only improve the clinical manifestations of the PSS patients, but protects the VECs from injury and has a good therapeutic effect on PSS patient.更多还原