【摘要】 目的　了解血清降钙素基因相关肽 (CGRP)与冠心病的关系。方法　用断面调查的方法收集经冠状动脉造影确诊的冠心病患者 119例、非冠心病患者 78例及同期健康体检 39例 ,测定CGRP水平。结果　冠状动脉粥样硬化病变的发生与年龄、吸烟及糖尿病明显相关 ,与CGRP的降低明显相关。多因素分析证实糖尿病、年龄、吸烟的OR均大于 1,差异并有显著性 ;CGRP的OR小于 1。用前进法观察糖尿病、年龄、吸烟的偏回归系数的变化证实这几个因素是冠脉病变的独立危险因素 ;CGRP是冠脉病变的独立保护因素。结论　罹患糖尿病、年龄大和吸烟是导致冠心病重要而各自独立的危险因素。CGRP是冠状动脉病变的独立保护因素更多还原

【Abstract】 Objective To investigate the relationship between serum calcitonin gene related peptide (CGRP) and coronary angiopathy Methods In a cross sectional study, serum CGRP levels of 119 patients with coronary heart disease (CHD), 78 with non CHD and 39 healthy subjects were measured with radioassay method The information on conventional risk factors were collected by interviews Results The development of coronary angiopathy was correlated with smoking, diabetes and aging The mean serum CGRP level was significantly lower in CHD than in NCHD patients [(35 5±48 8) μmol/L vs (63 8±47 3) μmol/L, P <0 01) There was no difference between the mean serum CGRP level in NCHD patients and healthy controls By multivariate logistic regression, the odds ratios (OR) of aging,smoking and diabetes were all ≥1 ( P <0 01),that means they are independent risk factors for the development of coronary angiopathy The OR of CGRP was ≤1, indicating that it was an independent protective factor [WT5"HZ]Conclusions It is shown that aging, smoking and diabetes are all independent risk factors for the development of angiopathy, while CGRP is an independent protective factor for the development of coronary angiopathy更多还原