【摘要】 目的　探讨拮抗内皮素 (ET)在体外冲击波碎石术 (ESWL)致肾脏急性损伤中的防治作用。　方法　 6 0例行ESWL治疗的肾盏、肾盂内结石患者 ,随机分为硝苯地平组和对照组 ,各 30例。硝苯地平组在ESWL前 3d口服药物 ,对照组不服用任何药物。 2组分别于ESWL治疗前 1d、后 1d、后 1周采用放射免疫法测定血浆ET ,同时测定 2 4h尿微球蛋白 (β2 M )、TH糖蛋白 (TH P)等变化。　结果　ESWL后对照组ET、β2 M均明显高于治疗前 (P <0 .0 0 1) ,尿TH P则明显低于治疗前水平(P <0 .0 0 1) ,差别有显著性意义。硝苯地平组ESWL后ET、β2 M均比治疗前增加 ,尿TH P降低 ,但差别均无显著性意义 (P >0 .0 5 )。　结论　硝苯地平能够拮抗ESWL致急性肾脏损害患者的血浆内皮素 ,对ESWL导致的急性肾功能损害有保护作用更多还原

【Abstract】 Objective To study the effect of nifedipi ne ,an endothelin antagonist,in acute renal function impairment caused by ESWL. Methods 60 cases of renal stone underwent anaesthesia-free ESWL were radomely assigned into 2 groups,the nifedipine group and the control (n=30 each).In the former group,nifedipine was given 3 days before ESWL.Plas ma endothelin,urinary β 2-microglobulin,and urinary Tamm-Horsfall protein we re assessed to evaluate the renal function. Results In t he controls,it was a significant increase of plasma endothelin and urinary β 2-MG(P<0.001) after ESWL.In the nifedipine group,ET and β 2-MG also incr eased and urinary TH-P decreased after ESWL but statistically insignificant. Conclusions Nifedipine would antagonist the plasma endoth elin in acute renal function impairment caused by ESWL.So,it may protect the ren al function from impairment caused by ESWL.更多还原