【摘要】 目的　探讨慢性排斥移植肾中细胞间粘附分子 1(ICAM 1)和HLA DR表达与间质淋巴细胞浸润的关系。　方法　对 2 0例慢性排斥肾移植受者进行肾活检 ,采用免疫组化技术 (ABC法 )检测移植肾内ICAM 1和HLA DR的表达。　结果　ICAM 1在慢性排斥移植肾肾小管上皮细胞和间质微小动脉内皮细胞表达增强 ,而HLA DR表达则普遍上调 ,尤其在远曲小管。此外 ,在I CAM 1和HLA DR表达增强的局部血管周围和小管间质伴有大量淋巴细胞浸润。　结论　慢性排斥移植肾中ICAM 1和HLA DR表达增强可能在排斥反应中起诱导作用 ,尤其是间质炎细胞的浸润及抗原递呈 ,同时它们又可能使表达上调的细胞成为免疫反应效应支的靶细胞 ,从而参与慢性排斥的细胞免疫损伤及移植肾间质损害过程更多还原

【Abstract】 Objective To study the relationship between the expression of ICAM-1,HLA-DR in the renal allograft of chronic rejection. Methods The expression of ICAM-1 and HLA-DR was assessed in 20 cadaveric renal allografts with chronic rejection using immunohistological techniqu(ABC method). Results In the renal allograft with chronic rejection,the expression of ICAM-1 was increased on the tubular epithelial cells and interstitial microvascullar endothelium,whereas the expression of HLA-DR was up-regulated,especially on the distal tubules. In addition, the expression of ICAM-1 and HLA-DR was associated with lymphcytes infiltration in the local perivascullar and intertubular structure. Conclusions It is suggested that the increased ICAM-1 and HLA-DR expressions might mediate allograft injury and have a role in the augmentation of the response,either in its induction,especially in the interstitial lymphocytes infiltration and antigen presenting or as a target for the effector arm of the reaction.更多还原