【摘要】 目的　研究胃癌患者的生存期与个性特征、应付方式等心理因素 ,以及免疫功能的关系。方法　对胃癌晚期患者 (胃癌Ⅰ组 )、胃癌较长生存期患者 (胃癌Ⅱ组 )及正常健康人 (对照组 )分别进行明尼苏达多相个性测验 (MMPI)、应对方式问卷 (CSQ)、免疫功能测试 ,并做相关分析。结果(1)MMPI:胃癌Ⅱ组人格障碍评分 (42 0± 10 5 )及社会内向评分 (42 2± 11 6 ) ,低于其他两组 [胃癌Ⅰ组为 (49 3± 11 2 )分和 (48 3± 9 4)分 ,对照组为 (48 6± 10 9)分和 (39 9± 11 5 )分 ;P均 <0 0 5 ];(2 )CSQ :解决问题和求助因子分 ,胃癌Ⅰ组 [分别为 (0 6 8± 0 2 7)分和 (0 42± 0 18)分 ]均低于胃癌Ⅱ组[分别为 (0 82± 0 18)分和 (0 6 5± 0 2 1)分 ;P <0 0 5和P <0 0 1],胃癌Ⅱ组更多采取成熟的应对方式 ;(3)自然杀伤细胞 (NK细胞 ) :胃癌Ⅱ组水平 (2 1 4± 9 2 )高于胃癌Ⅰ组 [(14 2± 8 8) ;P <0 0 5 ];而NK细胞水平与MMPI的抑郁 (r =- 0 35 )、人格障碍 (r=- 0 39)、偏执 (r =- 0 2 9)、精神衰弱 (r =- 0 30 )及精神分裂 (r=- 0 30 )等量表呈负相关 ,与CSQ的解决问题因子 (r =0 35 )及应付方式类型(r=0 34)呈正相关。结论　与胃癌Ⅰ组比较 ,胃癌Ⅱ组更为外向 ,负性情绪较少 ,更多采取成熟更多还原

【Abstract】 Objective To study the mechanism in which the personality, copying style influenced survival time by changing immunity function in the patients with gastric cancer Methods The Minnesota Multiphase Personality Inventory (MMPI), coping style questionnaires (CSQ) and immunity function were measured in patients with gastric cancer on late stage (groupⅠ), gastric cancer patients with longer survival time (groupⅡ), and normal control Results Psychopathic deviate, social introversion subscale scores of MMPI in groupⅡ were significantly lower than that in the other two groups ( P <0 05) Statistical difference were found between groupⅠand groupⅡ in problem saving factor (SP) and help seeking factor of CSQ ( P <0 05) Natural killer cell (NKC) level in groupⅡ was significantly higher than in groupⅠ( P <0 05) There was negative correlation between the NKC and depression, psychopathic deviate, paranoia, psychasthenia, schizophrenia subscale scores of MMPI, there was positive correlation between NKC and SP, coping type in patients with gastric cancer Conclusion The gastric cancer patients with longer survival time are more extroversive and have more mature coping styles Their NKC level is relatively higher The results may be advantageous to improve the prognosis of gastric cancer更多还原