【摘要】 目的　探讨单克隆抗体MG7、MGd1在卵巢肿瘤中的表达与临床相关性。方法　采用免疫荧光流式细胞术检测 10例正常卵巢组织、2 4例良性卵巢肿瘤及 48例恶性卵巢肿瘤细胞中MG7、MGd1的FI值 ,并进行比较分析。结果　卵巢恶性肿瘤的MG7、MGd1FI值及阳性表达率明显高于良性肿瘤组 (P <0 .0 5 ) ,卵巢粘液性癌的阳性表达率明显高于浆液性癌 ,宫内膜样癌 (P均 <0 .0 5 )。而恶性生殖细胞肿瘤MG7、MGd1的表达率均为 80 % ,与粘液性癌无显著差异 (P >0 .0 5 )。 5例卵巢转移性腺癌中 ,有 2例胃肠道来源的肿瘤MG7、MGd1为阳性表达。良性肿瘤中有 1例复发性粘液性瘤 ,其MG7,MGd1均为阳性 ,而其余MG7或MGd1为阳性表达者均为生殖细胞肿瘤。结论　免疫荧光流式细胞术检测卵巢肿瘤组织中单克隆抗体MG7、MGd1的表达 ,是诊断卵巢癌的一种可行的方法 ,可作为卵巢粘液上皮癌的监测指标。并证实了胃癌与卵巢癌具有共同抗原 ,从而可帮助判断卵巢转移性肿瘤的组织来源。更多还原

【Abstract】 Objective To discuss the expression of monoclonal antibody MG 7,MG d1 in ovarian tumors and their clinical correlation. Methods The content of FI MG 7,MG d1 wase measured by immunofluorescance Flow cytometry in 48 patients with malignant ovarian tumor,24 cases benign ovarian tumor and 10 normal ovaries, and the results had been analysed. Results The content of FI and expression rate of MG 7,MG d1 in ovarian malignant tumors was higher than that in benign ovarian tumors (P< 0.05 ). The expression rate of MG 7、MG d1 in ovarian mucous cystadencarcinoma was higher than in serous cystadencarcinoma,endometrioid tumors (P< 0.05 ). The expression rate of MG 7,MG d1 in malignant germinoma has no obvious difference with mucinous cystadencarcinoma. In 5 metastatic adenocarcinoma MG 7,MG d1 expressed in 2 cases,which all came from gastrointestinal tract tumors. In benign ovarian tumors, MG 7,MG d1 were expressed in one recurrent mucous cystadenoma, and others which have expression of MG 7 or MG d1 were germinoma. Conclusion The detention measurement of monoclonal antibody MG 7,MG d1 is more reliable method for diagnosing malignant ovarian tumors and is a means to monitor mucous cystadenocarcinoma. The results also confirmed that ovarian cancers and gastric carcinoma have the same antigen, so it is helpful to distinguish and diagnose the origination of ovarian metastatic tumors.更多还原