【摘要】 [目的]调查广州市女性乳腺癌的危险因素 ,为乳腺癌的防治提供依据。[方法]采用1∶1配对的病例对照研究方法 ,问卷调查1997年1至6月348例年龄范围在30岁～74岁、经病理组织学确诊的女性乳腺癌生存病例。调查内容包括一般情况、生活居住环境、饮食习惯、生活方式、疾病和家族史、女性生理与生育等6个方面的问题。用相对危险度的近似估计值比数比(Oddratio,OR)估计危险因子与乳腺癌的联系强度 ,用Logistic回归模型进行单因素和多因素分析筛选出有意义的危险因素。[结果]经多因素分析 ,与乳腺癌发病有关的变量为十年前鱼虾月均进食量大、缺乏体育锻炼、被动吸烟、精神压抑、月经不规律及生殖系统手术史(P<0.05) ,对乳腺癌有保护作用的变量为经常进食葱类食品和生育(P<0.05)。[结论]10年前鱼虾月均进食量大、缺乏体育锻炼、被动吸烟、精神压抑、月经不规律及生殖系统手术史是乳腺癌的危险因素 ,经常进食葱类食品和生育是乳腺癌的保护因素更多还原

【Abstract】 A case control study was conducted to explore the risk factors of female breast cancer in Guangzhou.Three hundred and forty_eight female cases with breast cancer survivors (age range from 30 to 74 years) were surveyed by questionnaire,matched1∶1 with contorls between January and June,1997.Survey included general condition,living environment,diet habit,living style,disease and family history,menstuation and fertility.Correlation power of all risk factors with breast cancer was evaluated by the odd ratio (OR).Logistic regression model univariate and multivariate analysis were used for screening the significant risk factors of breast cancer. High monthly fish and shrimps consumption 10 years ago,lack of physical exercises,passive smoking,mental depression ,irregular menstruation,history of operation in reproductive system were associated with increased risk of breast cancer (P<0.05).High onion food consumption and fertility decreased risk of breast cancer (P<0.05).[Conclusions] High monthly fish and shrimp consumption 10 years ago,lack of physical exercises,passive smoking,mental depression,irregular menstruation,history of operation in reproductive system were the risk factors of breast cancer.High onion food consumption and fertility were the protective factors of breast cancer.更多还原