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胃癌的家族聚集性研究

Study on Familial Aggregation in the Occurrence of Gastric Cancer

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【作者】 覃玉徐耀初沈洪兵周玲李建树喻荣彬钮菊英郭剑涛徐爱玲王志华贺兴胡旭徐天亮开海涛

【Author】 QIN Yu,XU Yao-chu,SHEN Hong-bing,et al. (Department of Epidemiology, Nanjing University of Medical Science,Nanjing 210015,China)

【机构】 南京医科大学流行病学教研室!江苏南京210015南京医科大学研究生现在江苏省疾病预防控制中心工作南京医科大学流行病学教研室!江苏南京21

【摘要】 本文采用遗传流行病学病例对照研究方法 ,探讨遗传因素在胃癌病因中所起的作用 ,并研究胃癌的家族聚集性。结果病例组有胃癌家族史的比例 (22.53% )显著高于对照组 (10.79% ) ,病例组一级亲属患胃癌的比例 (3.21% )高于对照组(1.44% ,OR=2.27,95%CI1.38~3.73)。用(p+q)n 模型拟合结果家族中实际病例数的分布高于二项分布的概率范围 ,经频数分布拟合优度的检验 ,P<0.01,说明胃癌在家族中并非按机会均等的概率分布 ,而是呈现明显的家族聚集现象 ,胃癌家族史是胃癌发生的危险因素。

【Abstract】 We analyzed Familial Aggregation in the occurrence of gastric cancer (GC) on the basis of a population_based case_control study conducted and synthetically evaluated the role of genetic factor. There were 182 proband ancestries and 241 control ancestries. The result showed that the positive family history of GC in probands (22.53%) was higher than that in controls (10.79%,P<0.01). The GC prevalence in first_degree relatives of probands (3.21%) was higher than that in controls (1.44%,OR=2.27, 95%CI1.38~3.73). The distribution of GC in the predigrees of probands was significantly different from that in controls. It is showed that there is significant familial aggregation in the occurrence of GC in the first_degree relatives of probands, and the GC family history is one of the important risk factors.

【关键词】 胃肿瘤遗传家族聚集性
【Key words】 gastric neoplasmsfamily historyfamilial aggregation
  • 【文献出处】 中国肿瘤 ,Bulletin of Chinese Cancer , 编辑部邮箱 ,2001年09期
  • 【分类号】R735.2
  • 【被引频次】28
  • 【下载频次】250
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