【摘要】 本文采用遗传流行病学病例对照研究方法 ,探讨遗传因素在胃癌病因中所起的作用 ,并研究胃癌的家族聚集性。结果病例组有胃癌家族史的比例 (22.53% )显著高于对照组 (10.79% ) ,病例组一级亲属患胃癌的比例 (3.21% )高于对照组(1.44% ,OR=2.27,95%CI1.38～3.73)。用(p+q)n 模型拟合结果家族中实际病例数的分布高于二项分布的概率范围 ,经频数分布拟合优度的检验 ,P<0.01,说明胃癌在家族中并非按机会均等的概率分布 ,而是呈现明显的家族聚集现象 ,胃癌家族史是胃癌发生的危险因素。更多还原

【Abstract】 We analyzed Familial Aggregation in the occurrence of gastric cancer (GC) on the basis of a population_based case_control study conducted and synthetically evaluated the role of genetic factor. There were 182 proband ancestries and 241 control ancestries. The result showed that the positive family history of GC in probands (22.53%) was higher than that in controls (10.79%,P<0.01). The GC prevalence in first_degree relatives of probands (3.21%) was higher than that in controls (1.44%,OR=2.27, 95%CI1.38～3.73). The distribution of GC in the predigrees of probands was significantly different from that in controls. It is showed that there is significant familial aggregation in the occurrence of GC in the first_degree relatives of probands, and the GC family history is one of the important risk factors.更多还原