【摘要】 [目的]复查鼻咽癌高发区2610例鼻咽癌的病理组织学类型 ,比较未经治疗和复发性鼻咽癌在组织学类型构成方面的差异,以反映高发区鼻咽癌病理组织学类型构成的特点。[方法]复查1999年至2000年鼻咽活检4503人次 ,有适合组织学分型的鼻咽癌2610例。其中2370例是未经治疗的 ,240例是复发性的。比较未经治疗与复发性鼻咽癌病理组织学类型的构成。[结果]根据世界卫生组织的分型标准 ,绝大多数未经治疗的鼻咽癌 (2292/2370,96.71% )是非角化性癌 ,仅55例 (55/2370,2.32% )为角化性鳞状细胞癌。在2292例非角化性癌中 ,2088例 (2088/2292,91.10 % )是鼻咽型未分化癌。与未经治疗的鼻咽癌相比 ,角化性鳞状细胞癌在复发性鼻咽癌中所占的百分率(24/240,10%)以及分化型非角化性癌在非角化性癌中所占的百分率(40/214,18.69%)均显著增高(P<0.001)。[结论](1)在鼻咽癌高发区(广州)所见的鼻咽癌大多数是非角化性癌,其中以鼻咽型未分化癌占绝对优势 ;(2)在未经治疗的鼻咽癌中,角化性鳞状细胞癌和非角化性癌两大类在平均年龄和男女比例方面没有差异 ;(3)在经放疗后的复发性鼻咽癌中 ,分化较好的类型比率增高。更多还原

【Abstract】 To review the histopathological types of 2610 cases with nasopharyngeal carcinomas (NPCs) seen in high-incidence area and to compare the constitutions of histological types between untreated and recurrent NPCs cases. The authors reviewed all samples of biospies from the 4503 cases with nasopharyngeal in the period of 1999～2000.Of them 2610 NPCs were suitable for histopathological typing. Among the 2610 NPCs, 2370 cases were untreated and 240 recurrent. The constitution of histological types between untreated and recurrent NPCs were compared. According to the criteria of WHO classification, the vast majority of untreated NPCs (2292/2370, 96.71%) was non-keratinizing carcinoma (NKC),only 55 NPCs (55/2370, 2.32%) keratinizing squamous cell carcinoma (KSCC). Two thousand and eighty-eight out of 2292 NKCs (2088/2292, 91.10%) were undifferentiated carcinoma of nasopharyngeal type (UCNT). As compared with the untreated NPCs, the KSCCs and the differentiated non-keratinizing carcinomas (DNKCs) in recurrent NPCs were both significantly increased in percentages (P<0.001). [Conclusions] (1) The majority of NPCs seen in high-incidence area of NPC is NKC to type and the UCNT subtype is predominant. (2) As regards the mean ages and the ratio of male to female, there is no difference between KSCCs and NKCs in untreated NPC patients. (3) In contrast with the untreated NPCs, the recurrent NPCs become more differentiated after radiotherapy.更多还原