【摘要】 目的　探讨血清白细胞介素 6 (IL 6 )和可溶性IL 6受体 (sIL 6R)水平与煤工尘肺的关系及临床意义。方法　采用ELISA法检测 5 6例煤工尘肺患者及 12 6名有相同接尘史但未患尘肺的煤矿工人 (对照组)血清IL 6及sIL 6R的水平。结果　尘肺患者血清IL 6平均水平为 (14.0± 13.1)pg/ml,高于对照组[(7.2± 8.2 )pg/ml],差异有显著性 (P <0 .0 1)。多元线性回归分析表明 ,尘肺患者血清IL 6水平与尘肺期别呈正相关 (r =0 .45 1,P <0 .0 1) ;尘肺患者血清sIL 6R水平与对照组的差异无显著性 (P >0 .0 5 )。结论　IL 6可能参与了尘肺的发病过程 ,测定尘肺患者血清IL 6可能对病情监测有一定参考价值更多还原

【Abstract】 Objective To investigate the relation between serum interleukin 6(IL 6),its soluble receptor(sIL 6R) and coal workers’ pneumoconiosis(CWP),and clinical significance. Methods Levels of serum IL 6 and sIL 6R were measured in 56 miners with CWP and 126 miners without CWP by using ELISA method. Results The mean levels of IL 6 in miners with CWP were significantly increased,compared with that of miners without CWP[(14.0±13.1)pg/ml vs. (7.2±8.2)pg/ml, P <0.01].Multiple linear regression analysis revealed that levels of serum IL 6 were significantly correlated to CWP stages( r =0.451, P <0.01).On the other hand,no significant difference was observed in serum sIL 6R levels between miners with or without CWP. Conclusion IL 6 may be involved in the pathogenesis of CWP.Measuring the level of serum IL 6 in patients with pneumoconiosis may be of certain value to monitor the patients’condition.更多还原