【摘要】 目的　探讨与老年男性骨质疏松症发生有关的骨代谢指标变化特点及意义。方法　采用放射免疫分析法对 5 8例老年男性骨质疏松和 37例骨量减少患者进行血清白细胞介素 1β(IL 1β)、类胰岛素样生长因子Ⅱ (IGF Ⅱ )、甲状旁腺素中段 (PTH M)和 2 5 羟基维生素D(2 5 OH D)的含量和骨密度检测 ,同时与青中年和老年健康人进行比较。结果　老年男性骨质疏松和骨量减少患者IL 1β和PTH M水平不同程度高于不同年龄对照组 ,而IGF Ⅱ和 2 5 OH D水平则低于对照组 ,尤以骨质疏松组降低明显 (P <0 .0 1)。随着年龄增长和病情加重 ,两组患者骨密度均明显低于青中年对照组 (P <0 .0 1)。老年男性骨质疏松组骨密度明显低于骨量减少组 (P <0 .0 5 )。结论　细胞因子等骨代谢指标紊乱是造成老年男性骨质疏松症的重要因素。更多还原

【Abstract】 Objective To investigate the characteristics and significance of the changes of bone metabolism indexes related to the occurence of osteoporosis in aged males. Methods Serum interleukine 1β(IL 1β),insulin like growth factorⅡ(IGF Ⅱ),parathyroid hormone(PTH M) and 25 OH D were measured by radioimmunoassay in 58 aged males with osteoporosis and 37 cases with bone mass loss. Bone density was measured in these subjects and all the indexes were compared with those in young and middle aged and aged healthy controls. Results IL 1β and PTH M levels in aged males with osteoporosis or bone mass loss were higher than those in healthy controls( P <0.01), while IGF Ⅱ and 25 OH D were lower than in normal controls, especially in osteoporosis group ( P <0.01). With the age increasing and the deterioration of the disorder, bone density in the two groups of patients were significantly lower than those in young and middle aged controls ( P <0.01). Aged males with osteoporosis had a significantly lower bone density than patients with bone mass loss. Conclusion Cytokines and disturbance of bone metabolism indexes are the main factors that lead to osteoporosis characterized by more bone absorption and less bone formation in aged males.更多还原