【摘要】 目的　观察低温海水淹溺濒死大鼠不同时间血气与酸碱代谢的改变 ,分析形成原因和机制 ,为治疗提供理论依据。方法　置动物于 16～ 17℃海水自由游动 ,直至沉入水底 ,呼吸暂停 ;取出后于不同时间测量肛温 ,心脏取血检测血气与酸碱 ,处死动物称取肺湿重计算肺脏 /体重比值。结果　大鼠出海水后的肛温、Pa O2 、Pa SO2 (% )、p H、BE- EC、BE- B、SBC、HCO- 3 及 TCO2 均明显降低 ,而肺脏 /体重比值及 Pa CO2 则显著升高 ;上述指标随时间延长均呈恢复趋势 ,但大多数指标至 6 0 m in仍未回到正常对照水平。结论　低温海水淹溺濒死大鼠 ,主要受低温海水浸泡和低温海水吸入呼吸系统所致侵害 ;前者导致代谢性酸中毒 ,后者则引起低氧血症、高碳酸血症、呼吸性酸中毒及代谢性酸中毒。更多还原

【Abstract】 Objective To observe the changes of blood gas and acid base unbalance in near drowning rats caused by hypothermic sea water and to investigate their pathogenesis so as to give theoretical basis of treatment. Methods Rats were put into 16~17℃ hypothermic sea water one by one to swim freely until they sank to the bottom with cyanosis and breath stop in about 15 minutes; then the rats were taken out of water quickly in room temperature and rectal temperature, left ventricular heart blood, blood gas and acid base at different times were examined until they were put to death. Finally, the rat′s wet lung weight and the ratio of wet lung weight with body weight were taken. Results pH,PaO 2,PaSO 2(%),BE EC,BE B,SBC,HCO - 3 and TCO 2 all decreased remarkably in 5,15,30 and 60 min groups as compared to normal control group( P <0 01), with the lowest point in 5 min group except that the PaCO 2 and wet lung/body weight ratio were markedly increased; and all these above parameters had a tendency to recover with time but most of them still not to normal in 60 minutes.Conclusions The near drowning rats were injured mainly by hypothermic sea water body immersion and pulmonary hypothermic sea water inhalation with the former inducing metabolic acidosis and the latter causing anoxemia, hypercapnia, respiratory acidosis and metabolic acidosis.更多还原