【摘要】 目的　探讨胆道梗阻及缓解过程中肝脏代谢胆红素的机制。方法　利用Wistar大鼠梗阻性黄疸模型 ,动态观察胆道梗阻不同时间及梗阻缓解后 ,血清胆红素变化规律。结果　实验结果表明 ,血清胆红素水平在梗阻早期 (<14d)明显升高 ,特别是血清δ 胆红素 ;梗阻 2周后及梗阻缓解后 ,血清胆红素水平下降 ,但δ 胆红素 /总胆红素比值升高。结论　胆道梗阻解除后可能存在的高胆红素血症期 ,并不提示预后不良更多还原

【Abstract】 Objective To investigate changes in serum bilirubin, especially δ bilirubin, after obstructive jaundice. Methods Two hundred and sixty Wistar rats weighing 300-350 g were employed in this study. Part of the rats were inflicted with obstructive jaundice through ligation of common bile duct (experimental group) and the left received sham operation (control group). Level of serum bilirubin was measured on the 1st, 3rd, 5th, 7th, 14th and 28th day after the ligation and on the 1st and 7th day after relief of biliary obstruction. Results Serum total bilirubin was significantly elevated in the experimental group, especially in the early stage of obstructive jaundice. After relief of biliary obstruction, the level of serum bilirubin decreased, but that of δ bilirubin and the ratio of δ/T-bilirubin remained higher. Conclusions High level of serum bilirubin after depression of obstructive jaundice is not just the sign of dysfunction of liver, but to some extent, the sign of recovery of liver function.更多还原