【摘要】 目的　评价全程加速超分割放射治疗食管癌的疗效。方法　 2 16例食管鳞癌病例随机分为 2个组 :⑴常规分割组 (CF) 110例 ,方法为 2Gy/次 ,5次 /周 ,总剂量 6 0～ 70Gy ,30～ 35分次 ,6～ 7周完成 ;⑵全程加速超分割组 (WCAHF) 10 6例 ,方法为 1.5Gy/次 ,2次 /d ,间隔 6h以上 ,总剂量 5 1～ 6 0Gy,34～ 40分次 ,3.3～ 4.0周完成。结果　CF组和WCAHF组的 1、3、5年生存率分别为 45 .5 %和6 9 .8%、2 0 .0 %和 40 .6 %、13.6 %和 33.0 % ,全程加速超分割组明显优于常规组 ,2个组差异有极显著性意义 (P <0 .0 1) ;而放射治疗副反应和并发症 2个组差异无显著性意义 (P >0 .0 5 )。结论　全程加速超分割放射治疗能明显提高食管癌患者的长期生存率 ,不明显增加放射治疗副反应及并发症更多还原

【Abstract】 Objective To evaluate the therapeutic effects of whole course accelerated hyperfractionation radiotherapy (WCAHR) for esophageal carcinoma.Methods From May 1989 to Dec. 1994, 216 patients with squamous cell carcinoma of esophagus were randomized into two groups:110 patients entered the convention fractionation radiotherapy (CFR) group and 106 the WCAHR group. The patients of CFR group received a total dose of 60～70 Gy,at 2 Gy daily,5 days per week.While,in the WCAHR group,D T 51～60 Gy/34～40 fs/3.3～4.0 wks were delivered,at 1.5 Gy twice daily with a minimum interfraction interval of 6 hours,5 days per week.Results The 1 ,3 ,5 year survival rates were 45.5%,20.0%,13.6% in the CFR, and 69.8%,40.6%, 33.0% in the WCAHR , respectively. The survival rates in WCAHR group were much better than those in CFR group (P<0.01).There was no significant differences on acute complications or specific sequelae between the two groups.Conclusions The results from this study show that the whole course accelerated hyperfractionation radiotherapy regimen can notably improve the long term survival of esophageal carcinoma without increasing any untoward radioreactions or complications.更多还原