【摘要】 目的　探讨阴道使用雌激素治疗绝经后妇女反复泌尿系感染的效果及可行性。方法将 4 5例有反复泌尿系感染病史的绝经后妇女分成两组 ,分别使用结合雌激素 (商品名倍美力 ) ,软膏3 0例 (结合雌激素组 ) ,口服抗生素 15例 (抗生素组 ) ,疗程 3个月。用药前、后分别行清洁中段尿尿常规检查、尿及阴道细菌培养 ,对阴道细胞成熟值及阴道健康情况进行评估。同时测定子宫内膜厚度及血清雌二醇水平。结果　除结合雌激素组有 3例自行停止治疗外 ,其余均完成治疗。治疗后结合雌激素组泌尿系感染的发生率 ( 2 / 2 7)明显低于抗生素组 ( 12 / 15 ) ,两组比较 ,差异有极显著性 (P<0 0 0 1)。结合雌激素组阴道乳酸杆菌检出率达 5 9 3 % ,抗生素组无乳酸杆菌出现。结合雌激素组阴道健康评分 ( 13 4± 2 5 )分 ;阴道细胞成熟值 ( 74 6± 14 1) ,分别明显高于抗生素组 ( 5 2± 0 4分 ;10 8± 8 3 ) ,两项组间比较 ,差异均有显著性 (P <0 0 5 )。结论　阴道局部使用雌激素 ,能有效减少绝经后妇女泌尿系感染的反复发作 ,较使用抗生素副反应轻 ,治疗效果明显提高。更多还原

【Abstract】 Objective To evaluate the effect and feasibility of using estrogen cream for the prevention and treatment of recurrent urinary tract infection (UTI) in postmenopausal women Methods Forty five postmenopausal women with a history of recurrent UTI were divided into two groups (group premarin and group antibiotic) Participants were assigned to apply intravaginal premarin cream (group premarin, n =30) or oral antibiotic (group antibiotic, n =15) for 3 months respectively Urine routine test, midstream urine and vaginal cultures, vaginal health score (VHS), vaginal cell maturation value (MV), endometrial thickness and blood estrogen level were obtained before and after the study Results The incidence of UTI in the group premarin was significantly reduced as compared with that in the group antibiotic (2/27 vs 12/15, P <0 001) In the group premarin Lactobacilli reappeared (from 0 to 59 3%) and MV (from 9 2±6 8 to 74 6±14 1) and VHS (from 5 2±0 4 to 13 4±2 5) were improved after 3 months There was no significant change in the group antibiotic Conclusion It seems that intravaginal use of estrogen cream would effectively prevent and reduce the UTI in postmenopausal women更多还原