【摘要】 目的 :制备稳定的、易再分散的葫芦素聚乳酸毫微粒 (Cu PLA NP)冻干针剂。方法 :选用适宜填充剂制备Cu PLA NP冻干针剂 ,并评价其相关理化性质。结果 :冻干前后毫微粒形态、粒径、pH、包封率及载药量无明显变化 ,再分散性良好 ,制剂稳定 ,含水量合格。其临界相对湿度为 6 9.5 2 %。结论 :在适宜的处方及工艺条件下制备的Cu PLA NP冻干针剂是可行的更多还原

【Abstract】 Objective:To prepare stable and redispersable Lyophilization injection of cucurbitacin polylactic acid nanoparticles(Cu PLA NP).Method:An optimal supporting agent was chosen to prepare the Cu PLA NP lyophilization injection.The physical and chemical properties of the injection were evaluated.Result:The shape,diameters,association ratio,drug loading and pH of Cu PLA NP colloidal solution and lyophilization injection were not changed.The content of water consisted with the requirement of lyophilization injection.The critical relative humidity was 69.52%.The stability was good.Conclusion:It is practicable to prepare Cu PLA NP lyophilization injection with proper formulas and preparation processes. [更多还原