【摘要】 目的 :研究血管收缩因素ET 1和TXA2 、舒张因素PGI2 以及TXA2 与PGI2 的平衡与深静脉血栓形成 (DVT)的关系 ,为防治措施的进一步改进提供依据。 方法 :36例DVT患者根据病程分为A、B、C、D 4组 ,并设正常对照组。均采用放免的方法测定血浆ET 1、TXB2 、6 -keto -PGF1α浓度。 结果 :①DVT各组的血浆ET 1水平均高于对照组 (P <0 0 1)。②A组、B组和D组血浆TXB2 水平均高于对照组并有显著性差异 (P <0 0 1)。③C组血浆 6 -keto-PGF/ 1α水平低于对照组并有显著性差异(P <0 0 5 )。B组与A组和C组均有显著性差异 (P <0 0 5 ) ,B组分别高于A组和C组 (P <0 0 5 )。④DVT各组TXB2 与 6 -ke to -PGF1α比值 (T/P)均高于对照组并有显著性差异 (P <0 0 5 )。A组高于B组并有显著性差异 (P <0 0 5 )。 结论 :DVT存在血管收缩与舒张的失调 ,血管收缩强于血管舒张。血管收缩与舒张失调参与了DVT的病理生理过程 ,可能是血栓形成的辅助因素更多还原

【Abstract】 To evaluate the relationship between DVT and the factors on vascular contraction or dilation Methods:Thirty-six cases of DVT were divided into 4 groups according to the course of diseases.In group A of 12 cases of acute thrombosis,the course of diseases was 1～10days;Group B of 11 cases with stabilization,lasting 11～30 days;Group C of 8 cases of chronic convalescence,for 31～60 days;Group D of 5 cases of chronic convalescence with recent recurrance.In all cases of DVT groups and control ones blood plasma levels of ET-1?TXB 2?6-keto-PGF 1α were determined by radioimmunoassy. Results:①The plasma level of ET-1 of patients of group A?B?C and D was higher than that of the control( P<0 01 ).The plasma level of ET-1 was gradually increased from group A to group D ET-1 ( P>0 05 ).②The plasma level of TXB 2 in group A?B and D were higher than those in the control( P<0 01 ),and in group C also higher than in the control,but not significantly( P>0 05 ) ③The plasma level of 6-keto-PGF 1α of group C was lower than that of the control( P<0 05 ).In group A and D it was lower than in the control,but not significantly ( P>0 05 ).In group B it was higher than those of group A and C( P<0 05 ).④The ratio of TXB 2 and 6-keto-PGF 1α (T/P) of DVT groups had evident differences from the control( P<0 05 ),which was higher than that in the control.In group A it was higher than that in group B( P<0 05 ).Conclusion:The effect of vascular contraction was stronger than that of vascular dilation in DVT.The imbalance of vascular tension might be the assistant factor of DVT formation.更多还原