【摘要】 目的:探讨术前化疗对晚期乳腺癌雌激素受体含量的影响。方法:42例晚期乳腺癌患者分为两组。A组(31例):术前接受Cooper’s方案化疗1周。B组(11例):术前未进行化疗。术后对两组乳腺癌组织用MCG法测定雌激素受体含量,并比较两组之间有无显著差异。结果:A组雌激素受体平均含量为57.00fmol/mg蛋白质,B组雌激素受体平均含量为12.58fmol/mg蛋白质,A组与B组差异有显著意义(P<0.05)。结论:经术前化疗后雌激素受体含量较高,因此有必要在化疗前测定乳腺癌患者的雌激素受体含量,以便使所测得值准确地反映乳腺癌患者癌组织的真实受体状态,合理选择适当的治疗措施。更多还原

【Abstract】 Objective:To study the effect of pre-operative chemotherapy on the content of estrogen receptor in advanced breast cancer.Methods:Forty-two cases of advanced breast cancer were divided into two groups.Group A was treated by Cooper’s scheme for one week preoperatively.Group B received none treatment before operation,The estrogen receptor content of cancer tissues was assayed by MCG method postoperatively in both groups and the estrogen receptor content difference between these two groups was analysed.Results:The median estro-gen receptor content in group A was57.00fmol/mg and in group B was12.58fmol/mg,and the estrogen receptor contents in these two groups was statistically different (P<0.05).Conclusion:The estrogen receptor content is higher after pre-operative chemotherapy.It is necessary to de-tect the estrogen receptor content before chemotherapy so as to reflect the real status of estro gen re ceptor in cancer tissue of breast cancer patients and then to select the appropriate treatment.更多还原