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宫颈癌热放化随机分组治疗疗效
The Effects of Randomized Trial of Hyperthermo-Radio-Chemotherapy for Carcinoma of Uterine Cervix
【摘要】 目的:研究热、放、化疗三种因素对宫颈癌治疗的疗效。方法:1993年10月~1994年8月对120例宫颈癌患者随机分为单纯放疗组(A)、热放疗组(B)、放化疗组(C)、热放化疗组(D),治疗结束时评价近期疗效,随访5年生存情况。结果:治疗结束时完全缓解率(CR)从高到低依次为热放化疗组(D)83.3%、热放疗组(B)60.0%、放化疗组(C)50.0%、单纯放疗组(A)46.7%。近期疗效热放化疗组(D)明显好于其它3组(P<0.05)。A、B、C 3组疗效相近(P>0.05)。5年生存率从高到低依次为:热放疗组(B)和热放化疗组(D)均为76.7%、单纯放疗组(A)70.0%、放化疗组(C)66.7%。5年生存率4组之间无明显差异(P>0.05)。结论:热放化疗治疗宫颈癌近期疗效好,但未能延长生存期。
【Abstract】 Objective: To evaluate the effects of hyperthermo-radio-chemotherapy on carcinoma of uterine cervix Methods: From 1993 to 1994, one hundred and twenty patients with stage Ⅱb, Ⅲb cervical carcinoma were randomly divided into four groups: Group A (Radiotherapy alone), Group B (Hyperthmo-radiotherapy), Group C (Radio-chemotherapy) and Group D (Hyperthmo-radio-chemotherapy). The immediate response and 5-year survival rate were assessed. Results: After treatment, the CR of the Group D, C, B, A were 83.3%, 50.0%, 60.0% and 46.7% respectively. The short-term effect of Group D was the best among these groups (P<0.05), and the effects of the other three groups were similar (P>0.05). The 5-year survival rates of Group D, C, B and A were 76.7%, 66.7%, 76.7% and 70.0 respectively, with no significant difference among these four groups (P>0.05). Conclusion: Hyperthermo-radio-chemotherapy has a better short-term curative response for carcinoma of the cervix, but it does not prolong the survival rate.
- 【文献出处】 中国肿瘤临床 ,Chinese Journal of Clinical Oncology , 编辑部邮箱 ,2001年09期
- 【分类号】R737.33
- 【被引频次】14
- 【下载频次】108