【摘要】 目的：分析p16蛋白表达与大肠癌临床病理的关系。方法：应用LSAB免疫组化染色法，检测135例大肠癌p16蛋白表达情况，并分析p16蛋白表达与大肠癌临床病理的关系。结果：135例大肠癌p16蛋白的阳性率为59．26％，与正常粘膜比较差异有显著性（P＜0．01）。p16蛋白表达与大肠癌的病理分级、淋巴结转移及年龄有关，与临床分期无关。结论：p16蛋白越低，细胞恶性程度及淋巴结转移的机会越高，但p16蛋白与病期早晚关系不大。更多还原

【Abstract】 Objective： To study the relationship between expression of p16 protein and clinicopathology in colorectal cancer． Method： The expression of p16 protein in 135 patients with colorectal cancer were detected by immunohistochemistry （LSAB method） and the relationship between expression of p16 protein and its clinicopathology was evaluated． Results： The positive rate of p16 protein was 59．26％ and it was significantly different from normal mucous membrane （P＜0．01）． The expression of p16 protein was correlated with the histologic grade， metastasis of lymph nodes and the age of patients， but without the clinical stage． Conclusion： The results showed that the abnormal expression of p16 protein was associated with the onset of colorectal cancer， and the lower expression of p16 protein was associated with the higher malgnant degree and mnore chances of metastasis in colorectal cancer． The correlation was not found between the expression of p16 protein and the clinical stage in colorectal cancer．更多还原