【摘要】 目的　探讨应用放疗中化疗、序贯放化疗及单纯放射治疗晚期食管癌的疗效。方法　 1995年 7月至1996年 3月收治 12 5例晚期食管癌 ,随机分为放疗中化疗组 (4 5例 )、序贯放化疗组 (39例 )和单纯放疗组 (4 1例 )。放疗中化疗组于放疗开始后第 2日及第 30日予ELFP方案化疗各一周期 ,以后隔 4周后重复 ,共 5～ 6周期。序贯放化疗组于放疗完成后第 2 9日起予ELFP方案 ,隔 4周后重复 ,共 5～ 6周期。单纯放疗组直接给予放射治疗。食管癌放射治疗采用Co60 γ线照射 ,放射治疗剂量Dt6 0～ 6 6Gy,30～ 33次 ,6～ 6 .5周 ,常规分割。结果　随访至 1999年 10月 ,放疗中化疗组 1、2、3年生存率为 6 3.5 %、42 .6 %、17.8% ,序贯放化疗组 1、2、3年生存率为 6 0 .3%、18.1%、9.1% ,单纯放射治疗组 1、2、3年生存率为 6 0 .5 %、19.1%、10 .2 % ,三组生存率相比 ,放疗中化疗组有显著差异。结论　晚期食管癌应用放疗中化疗可提高生存率 ,副作用并不增加。更多还原

【Abstract】 Objective To compare the effect of radio-chemotherapy,radiotherapy followed by chemotherapy and single radiotherapy on esophageal cancer.Methods 125 patients with esophageal cancer were randomly divided into the radio-chemotherapy group of 45 cases,sequential radiotherapy-chemotherapy group of 39 cases and single radiotherapy group of 41 cases.In radio-chemotherapy group DT60～66GY was given 30～33 times in 6～6.5 weeks,beginning 2 days after the first cycle of ELFP regimen(VP-16 100mg day1～5,CF 200mg day1～5,5-FU 750mg day1～5,DDP 40mg day1～3).Chemotheray was repeated per four weeks for 5～6 cycles.In seguential radiotherapy-chemotherapy the same radiation followed by the same chemotherapeutic regimen as radio-chemotherrapy group was conducted.Single radiotherapy group was treated only by radiation(DT60～66GY/30～33times/6～6.5 weeks).Results The comparative observation of the three groups showed that the short term effects were similar.In the radio-chemotherapy group,3-year survival rate was higher than that of the other two groups.Conclusion Radio-chemotherapy is an effective and safe method for patients with esophageal carcinoma.更多还原