【摘要】 目的 :本文探讨了包封于脂质体中的维生素D2 体外透皮扩散能力的变化。方法 :将维生素D2 包封于脂质体中 ,并进一步制备成羧甲基纤维素钠的凝胶剂 ,与未包封于脂质体中的维生素D2 的羧甲基纤维素钠凝胶剂比较 ,进行了大鼠离体皮肤的扩散实验 ,比较不同类型的脂质体对维生素D2 透皮的影响。结果 :维生素D2 在游离状态下 ,不易进入皮肤层。维生素D2 脂质体可使维生素D2 在皮肤层中滞留 ,而且多室脂质体凝胶剂比单室脂质体凝胶剂在皮肤层中维生素D2 的滞留量多。结论 :脂质体作为维生素D2 皮肤局部给药的载体 ,能够提高对皮肤的穿透力更多还原

【Abstract】 OBJECTIVE To investigate the changes of liposomal vitamin D 2 in permeability through the rat skin in vitro. METHODS The rat skin diffusion of liposomal vitamin D 2 in carboxymethylcellulose sodium gel dosage form through was compared with non liposomal vitamin D 2 in the gel dosage form in vitro. RESULTS The permeability of non liposomal vitamin D 2 through the rat skin was poor.When vitamin D 2 entrapped in liposomes, the permeability of vitamin D 2 through skin increased and deposited in skin. The multilamellar vesicles detained a higher amount of vitamin D 2 than the unilamillar vesicles in skin. The amount of vitamin D 2 in the receiver cell did not increase significantly.CONCLUSIONS Liposomes can be used as a carrier of vitamin D 2 in topical application that increase the permeability through the rat skin.更多还原