【摘要】 目的　探讨雌二醇和人参总皂苷对去卵巢大鼠记忆障碍的改善作用及可能的机制。方法　利用成年去卵巢大鼠 ,通过Morris水迷宫方法观察去卵巢大鼠学习记忆功能的改变以及雌二醇和人参总皂苷对其改善作用 ,测定去卵巢大鼠胆碱乙酰转移酶 (ChAT)的活性并观察药物对此酶活性变化的影响。结果　雌二醇和人参总皂苷可以有效地阻止因去卵巢而造成的大鼠空间学习记忆能力的降低 ,并能逆转因去卵巢所引起的前脑皮层和海马中ChAT酶活性的降低。结论　雌二醇和人参总皂苷有改善因去卵巢所致大鼠记忆功能障碍的作用 ,其机制可能与它们能促进脑内乙酰胆碱的合成有关更多还原

【Abstract】 OBJECTIVE To study the effects of 17-β-estradiol(E 2) and total ginsenoside(tR) on the spatial learning and memory impairment induced by ovariectomy(OVX) and its mechanism of action.METHOD The change of the spatial learning and memory function, and the improving effect of E 2 and tR in adult OVX rats were observed using Morris water maze;The ChAT activity in frontal cortex and hippocampus was determined by acetylcoenzyme method, the improving effect of E 2 and tR for the ChAT activity was observed.RESULTS E 2 and tR significantly antagonized the decrease of spatial learning and memory induced by OVX and reversed the decrease of ChAT activity in frontal cortex and hippocampus induced by OVX.CONCLUSION E 2 and tR had the effect of improving spatial learning and memory impairment induced by OVX and this effect may correlate with the increase of Ach’s synthesis in brain.更多还原