【摘要】 目的 :观察 3 磷酸甘油醛脱氢酶的修饰蛋白 (modifierprotein ,MP)对急性肾功能衰竭 (acuterenalfailure ,ARF)大鼠肾间质内细胞间粘附分子 1(intercellularadhesionmolecule - 1,ICAM 1)的影响。方法 :利用庆大霉素致ARF的动物模型 ,将大鼠随机分成 3组 ,即正常对照组、模型组和MP组。分别测定各组血肌酐 (Scr) ,利用光镜、电镜观察肾组织学改变 ,并免疫组化染色标记ICAM 1的变化。结果 :MP组ICAM 1表达明显降低 ,与模型组相比 ,P<0 .0 1。同时光镜、电镜示MP组比模型组肾脏病理明显减轻。Scr下降 ,P <0 .0 1。结论 :MP可以降低ICAM 1表达 ,减轻ARF大鼠的肾脏病理改变 ,改善肾功能更多还原

【Abstract】 Objective: Our aim was to observe the effect of the modifier protein (MP) of glyceraldehyde 3 phosphate dehydrogenase (G3PD) on intercellular adhesion molecule 1(ICAM 1) in rats with acute renal failure (ARF) which were induced by gentamycin. Methods:The animal models of ARF were induced by gentamycin. SD rats were divided randomly into 3 groups: normal group, model group, and MP group. At the 7th and 14th day, the Scr was measured, the kidney was observed by using light and electron microscopy histologically, and the expression of ICAM 1 in the kidney was determined by immunohistochemistry method. Results:The expression of ICAM 1 decreased in the MP group (P<0.01). Meanwhile, Scr reduced(P<0.01). The light and electron microscopy showed only focal pathological changes which were lighter in the MP group than those in the model group. Conclusion:The MP can decrease the expression of ICAM 1 and lighten the pathological changes in rats with ARF, so recover the renal function.更多还原