【摘要】 目的 :探讨静磁场的生物学作用 ,为临床各领域的应用提供依据。方法 :将钐钴制成的圆锥形磁化与非磁化金属材料植入大鼠股骨内 ,并设未手术的正常对照组。观察 12周后分别利用二维X线吸收法装置 (DEXA)测定骨密度 (BMD)及利用OCPC法测定骨钙含量。结果 :植入磁化金属的大鼠股骨骨密度与骨钙含量均高于对应部位植入非磁化金属的大鼠 (P <0 .0 1) ,但前者的数值基本与未手术组相等。而在体重、血清Ca、血清ALP、末梢血各种细胞成分及肱骨、胫骨的骨密度 ,3组间未见显著差异。结论 :长期的局部静磁场刺激骨组织 ,可以预防骨密度下降。更多还原

【Abstract】 Objective: Our purpose was to evaluate the biologic effects of static magnetic fields in animal models. Methods: The specimens using tapered rods made of magnetized and unmagnetized samarium cobalt of the same size were implanted transcortically into the middle diphysis of rat femurs under press fit loading. The bone mineral density (BMD) and bone calcium content were measured 12 weeks after implantation by using dual energy X ray absorptiometry and chemical analysis with o cresolphthalein complexon, respectively. Results: The femurs adjacent to magnetized specimens had significantly higher BMD and calcium content than those adjacent to the unmagnetized specimen (P<0.01). However, the value of BMD and calcium content of rats with magnetized specimens were similar to those of non operated rats. No specific change was found in the body weight, serum calcium, activity of alkaline phosphatase, hemogram, and BMD of the tibia and humerus between the magnetized and unmagnetized groups. Conclusion: The long term local stimulation of static magnetic fields on the bone has a local effect to prevent the decrease in BMD.更多还原