【摘要】 目的 :研究结直肠癌患者血中 (insulin likegrowthfactorⅡ ,IGF Ⅱ )和 (transforminggrowthfactor α ,TGF α)水平的变化。方法 :采用放免分析法检测了 48例结直肠癌患者和 18例正常对照者血中IGF Ⅱ和TGF α的表达 ,并检测了其中 38例于术后半年接受随访的患者血中该两种物质的表达。结果 :结直肠癌患者血清IGF Ⅱ和TGF α水平明显高于正常对照组 ,且腺癌与粘液腺癌组间无差异。术后半年 ,接受随访的 38例患者 ,该两种物质水平较术前明显下降。有周围淋巴结转移者 ,其血中两种物质水平高于无转移者。结论 :血中IGF Ⅱ和TGF α的水平可较灵敏地反映消化系统肿瘤患者病情的变化 ,可以作为患者肿瘤转移程度及预后判断的指标更多还原

【Abstract】 Objective: Our aim was to study serum levels of insulin-like growth factor ( IGF-II) and transforming growth factor (TGF-α) in colorectal neoplasms. Methods: The serum levels of IGF-II and TGF-α in 48 serum samples of patients with colorectal neoplasms, 18 serum samples of controls, and 38 serum samples of patients who were followed postoperatively half of one year were measured by using radioimmunoassay. Results: The serum levels of IGF-II and TGF-α in colorectal neoplasms were higher than those of controls significantly, and no significant difference existed between adenocarcinomas and mucoadenocarcinomas. Serum levels of 38 patients who were followed postoperatively half of one year decreased significantly. Serum levels of IGF-II and TGF-α in patients with adjacent lymph node metastasis were higher than those without lymph node metastasis.Conclusion: Serum levels of IGF-II and TGF-α can accurately reflect the progression of digestive system tumors, and also can be used as markers for the extent of tumor metastasis and prognosis.更多还原