【摘要】 目的 :探讨血浆心钠素含量和肺灌注显像判定肺动脉高压的程度及其意义。方法 :对制作兔的肺动脉高压各期模型 ,抽静脉血 ,应用放免法测其血浆心钠素含量 ,判定肺动脉高压的程度 ,同时应用心导管法、肺灌注显像作对照。结果 :肺动脉压力轻度升高时 ,心钠素含量低于正常对照组 ,但无显著差异 (t=1,P >0 .0 5 ) ;心导管测得平均肺动脉压力 (m PAP)结果与正常对照组之间也无差异 ;肺灌注显像法获肺背侧、腹侧核素分布计数比值 ,明显高于正常对照组 ,其间有显著差异 (t=2 .5 ,P <0 .0 5 )。当肺动脉压力明显升高至中度、重度时 ,心钠素含量上升 ,与正常对照组之间有显著差异 (t分别为 4.0 ,6 .5 ;P <0 .0 1) ;另两种方法与正常对照组之间也有显著差异 (P <0 .0 1) ,此 3种方法呈正相关。结论 :血浆心钠素含量能判定肺动脉高压的程度 ,方法简单 ,但轻度压力升高时 ,不如肺灌注显像敏感更多还原

【Abstract】 Objective:Our aim was to study the levels of atrial natriuretic peptide (ANP) and pulmonary perfusion imaging in determining of pulmonary artery hypertension (PAH). Methods: We measured ANP levels by using radioimmunoassay after making various types of PAH in rabbits. Catheterization and pulmonary perfusion tomographic imaging were used in the control group. Results: When the pulmonary artery pressure increased slightly, the ANP levels were lower in PAH group than that of control group, but the difference was not significant (t=1, P>0.05). At the same time, pressure measured by catheterization did not change as the control group, but the ratio of back/abdomen radiopharmaceuticals distribution which was measured with pulmonary perfusion tomographic imaging was significantly higher in PAH group than that of the control (t=2.5, P<0.05). The difference between the ANP levels when the pulmonary artery pressure increased medially and seriously was significant (t=4.0 and 6.5, P<0.05). The other two methods got the same result (P<0 05). Results of three examining methods were positively related. Conclusion:The ANP levels can determine the degree of PAH, and it was simple. But it was not as sensitive as that of pulmonary perfusion tomographic imaging.更多还原