节点文献
药用甘氨酸α-晶体纯化新方法的研究
A Study on the New Purification Method of Medicine Glycine α-Crystal
【摘要】 首次报道在微量非离子表面活性剂存在下 ,以 3%~ 2 0 %的乙醇一次快速结晶药用甘氨酸α 晶体的工艺。探讨了结晶过程甘氨酸初始浓度、乙醇用量、结晶温度对晶体生长的影响。得到了最佳控制参数。产品各项指标均达到或超过美国药典水平。解决了甘氨酸贮运过程的结块问题。α 晶体率达 1 0 0 % ,纯度为 99 9% ,氯含量小于 0 0 0 3%。
【Abstract】 A new technical method of purifying the medicine glycine α crystal using nonionic surfactant and alcohol of concentration from 3% to 20% as crystallization solution was reported.The effect of initial concentration of glycine,amounts of alcohol and temperature on the crystalling process was studied.The best crystallinic condition was obtained.The purity of the crystal was 99 9%,the ratio of α crystal was 100%,and the content of chloride in glycine crystal was 0 003%.
【关键词】 快速结晶;
非离子表面活性剂;
甘氨酸α晶体;
【Key words】 medicine glycine α crystal; nonionic surfactant; rapid crystallinic method; ethyl alcohol;
【Key words】 medicine glycine α crystal; nonionic surfactant; rapid crystallinic method; ethyl alcohol;
- 【文献出处】 中国药物化学杂志 ,Chinese Journal of Medicinal Chemistry , 编辑部邮箱 ,2001年02期
- 【分类号】R914
- 【被引频次】16
- 【下载频次】168