【摘要】 目的 了解1983～1993年因输注同一批号的美国进口第Ⅷ因子导致HIV感染的4例血友病患者病程进展。方法 进行追踪观察。结果 发现最少注射剂量为955U,最多为2810U;均属HIV-1,B亚型,随病程发展,T4淋巴细胞明显下降,临床后期均有发热或腹泻,体重减轻30％以上,并出现各种机遇性感染,除1例因血友病复发1987年死于颅内出血,其余3例存活期分别为10,14,16年。结论 应加强血源管理;在营造一个宽松的社会环境使HIV感染者免受歧视的同时,也应教育感染者遵守国家法律,遵守社会公德;在艾滋病药价昂贵,疫苗尚未问世的现状下,健康教育仍是最经济最有效的良策。更多还原

【Abstract】 Objective To understand the progress of four haemophilia patients infected with HIV, subdivided into HIV - 1 B subtype, tlirough injecting factor Ⅷ imported from the US between 1983 and 1985.Methods Follow up observations were conducted a-mong the four haemophilia patients infected with HIV.Results Among the four patients, the minimum injecting dosage of fcator Ⅷ was 955 units, and the maximum was 2 810 units.Patients’ T4 lymphatic cell evidendy decreased with the progress of HIV infection.In the late stage period, all these patients had either fever or diarrhea, lost more than 30% of their body weight, and suffered from various conditions including reddish infections. One haemopllilia patient suffered a relapse and died from a brain hemorrhage. The other three cas-es lived for another 10, 14 and 16 years respectivly after they were infected with HIV. Condusion The author proposes that the man-agement of blood donors and blood products be made a priority, and that a social environment should be created to enable HIV infected carriers and patients to live free of contempt and without stigma. At the same time, HIV carriers and patients should be educated, in-creasing their knowledge and changing their behaviours to prevent HIV transmission to others.更多还原