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久居亚高原地区的冠心病患者血脂异常分析

Study of Lipids Ratios on Coronary Heart Disease at Subhigh Altitude

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【作者】 郭雪微盛铁仁谢萍杨泉郑云燕徐亚伟许澎陈维

【Author】 Guo Xuewei, Sheng Tieren, Xie Ping, et al. Department of Cardiology, Center for Cardiovascular Disease Research, Gansu Provincial People’s Hospital, Lanzhou (730000), Gansu

【机构】 甘肃省人民医院心内科甘肃省人民医院心内科 730000 甘肃省兰州市730000 甘肃省兰州市730000 甘肃省

【摘要】 目的:探讨久居亚高原地区的冠心病患者总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)和(TC-HDL-C)/HDL-C值异常及其它传统危险因素对冠心病发病的影响。 方法:分析105例冠状动脉造影(CAG)确诊的冠心病患者(冠心病组)及65例CAG阴性者(非冠心病组)的TC/HDL-C和(TC-HDL-C)/HDL-C值及血压、血糖、吸烟等与冠心病之间的关系。 结果:TC、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)浓度升高率在2组中无显著性差异,但TC/HDL-C、(TC-HDL-C)/HDL-C值异常率在冠心病组显著高于非冠心病组,有非常显著性差异(P<0.001),其比值升高与冠心病的危险性是非冠心病组的7倍。 结论:TC/HDL-C、(TC-HDL-C)/HDL-C值升高可能对亚高原地区冠心病发病更为敏感;冠心病的一级预防重点在于提高体内HDL-C水平,降低TC水平外,更重要的是调整二者之间的比值。

【Abstract】 Objective: To study the effects of ratios of total cholesterol/high density lipoprotein-cholesterol (TC/HDL-C) and total cholesterol - high density lipoprotein-cholesterol/high density lipoprotein-cholesterol [(TC- HDL-C)/HDL-C] on coronary heart disease (CHD)at subhigh altitude, Lanzhou (1517.2 m). Methods: Coronariography was performed in 170 patients with CHD symptoms. CUD was confirmed in 105 patients (CHD group). The other 65 patients were enrolled into control group. TC/HDL-C, (TC- HDL-O/HDL-C ratios and other risk factors were studied in both groups. Results: The abnormal ratios of TC/HDL-C and (TC- HDL-C)/HDL-C were significantly higher in CHD group than those in the control group (38.09% vs. 6.66% and 37.14% vs. 6.66%, p<0.0001). Patients with abnormal ratios of TC/ HDL-C and (TC- HDL-O/HDL-C had seven times increased risk for suffering from CHD (odds ratio>7.0). Conclusions: Besides high TC and low HDL-C concentrations, the ratios of TC/HDL-C and (TC- HDL-O/HDL-C are the most risk factors in developing CHD. They can be used as predictive indices for CHD at subhigh altitude.

  • 【文献出处】 中国循环杂志 ,Chinese Circulation Journal , 编辑部邮箱 ,2001年06期
  • 【分类号】R541.4
  • 【被引频次】4
  • 【下载频次】93
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