【摘要】 目的 :本研究试图研究心肌纤维化与高血压引起的左心室舒张功能障碍之间的关系及转化生长因子 β1在心肌纤维化形成中的作用。　　方法 :收集 83例原发性高血压病人 ,分为左心室舒张功能正常组、左心室舒张功能障碍组 ,根据Devereux标准分为左心室舒张功能障碍不伴左心室肥厚者、左心室舒张功能障碍伴左心室肥厚者 ,根据舒张早期最大峰值速度 /舒张晚期最大峰值速度 (VE/VA)值分为左心室舒张功能障碍伴VE/VA <1者、左心室舒张功能障碍伴VE/VA >1者。分别检测血清Ⅲ型前胶原、层粘蛋白、透明质酸、Ⅳ型胶原的含量及转化生长因子 β1。　　结果 :发现左心室舒张功能障碍组的转化生长因子 β1和纤维化指标除层粘蛋白及Ⅳ型胶原外 ,均明显高于左心室舒张功能正常组 ;尤其在左心室舒张功能障碍伴有左心室肥厚者及VE/VA >1者 ,并且与病程长短有关。转化生长因子 β1与血清Ⅲ型前胶原、层粘蛋白、透明质酸、Ⅳ型胶原的相关系数分别为 [0 5 35 6 (P <0 0 1)、0 0 86 4(P >0 0 5 )、0 15 2 7(P >0 0 5 )、0 2 0 2 0 (P >0 0 5 ) ]。　　结论 :在原发性高血压引起的左心室舒张功能障碍过程中发生了心肌纤维化 ,随着病程的进展 ,心肌舒张由弛缓性降低向顺应性降低发展 ,心肌纤维化程度进一步加重。而转更多还原

【Abstract】 Objective:This paper attemps to discuss the relationship between left ventricular(LV) diastolic dysfunction caused by essential hypertension and myocardial fibrosis and the role of transforming growth factor-β 1(TGF-β 1). Methods:Eighty-three patients with essential hypertension were divided into two groups:normal left ventricular diastolic function(NLVDF)and left ventricular diastolic dysfunction(LVDD).Based on the different standards,the latter was classified into:LVDD with mormal LV mass,LVDD with LV hypertrophy,LVDD with decreased relaxation and LVDD with decreased compliance.Precollagentype Ⅲ(PCⅢ),Laminin (LN),hyaluronan (HA),collagen type Ⅳ (Ⅳ-C) and TGF-β 1 were detected respectively. Results:There were significant differences of PCⅢ,HA,Ⅳ-C between NLVDF and LVDD.The relative coefficients between TGF-β 1 and PCⅢ,LN,HA,Ⅳ-C were 0.5356(p<0.01),0.0864(p>0.05),0.1527(p>0.05)and 0.202(p>0.05)respectively. Conclusion:Myocardial fibrosis develops with the occurrence of LVDD caused by essential hypertension,Myocardia fibrosis leads the decrease of relaxation to the decrease of compliance.TGF-β 1 may be play an important role in myocardial fibrosis.更多还原