【摘要】 目的　探讨新疆维吾尔族 (维族 )、汉族妇女宫颈糜烂与单纯疱疹病毒 (HSV)活动感染的关系。方法　用酶联免疫吸附实验 (ELISA)方法对 79例维族、12 8例汉族不同程度 (Ⅰ、Ⅱ、Ⅲ度 )宫颈糜烂病人和 2 9例维族、41例汉族正常对照进行血清HSV 1型和HSV 2型特异性IgM、IgG抗体检测 ,同时用聚合酶链反应 (PCR)检测上述病例和对照宫颈分泌物中HSV DNA。结果　维、汉族不同程度宫颈糜烂病人HSV 1IgM阳性率 (活动感染率 )分别为 2 7 8%和 2 6 8% ,正常对照维、汉族分别为 2 0 7%和 2 1 9% ,民族间、病例组和正常对照组间以及不同程度糜烂组间HSV 1活动感染率差异无显著 (P >0 0 5 )。维、汉族病例组HSV 2活动感染率分别为36 7%和 32 0 % ,显著高于正常对照组 13 8%和 9 8% (P <0 0 5 ) ,而维、汉族间不同程度糜烂组间差异无显著性 (P >0 0 5 )。维、汉族病例组HSV 2原发感染率为 16 5 %和 13 3% ,宫颈分泌物HSV DNA检出率维、汉族病例组分别为 36 0 %和 31 2 % ,显著高于正常对照组 13 8%和 7 3% (P <0 0 5 )。在病例组中 ,其HSV DNA检出率随糜烂程度的加重而升高。结论　新疆维、汉族妇女宫颈糜烂的产生和HSV 2活动感染有关。更多还原

【Abstract】 Objective To explore the relationship between the cervical erosion and the herpes simplex virus infection in Xinjiang Uighur and Han women.Methods The serum HSV 1 and HSV 2 specific antibody IgM,IgG were examined by ELISA method in 79 Uighur and 128 Han women who had different degrees of cervical erosion(Ⅰ°、Ⅱ°、Ⅲ°),and 29 Uighur and 41 Han women were as controls,meanwhile the HSV DNA in cervical secretions were also examined by polymerase chain reaction.Results In study group,the positive rates of HSV 1 IgM in Uighur and Han women were 27\^8% and 26\^8% respectively,in control group,it was 20\^7% and 21\^9% respectively.There was no significant difference between the two groups(P>0\^05).The positive rates of HSV 2 in study group(36\^7%,32\^0%)were higher than that in control group(13\^8%,9\^8%),the difference between the two groups was significant(P<0\^01),and the positive rates of HSV DNA of cervical secretion in study group(36\^0%,31\^2%)were also higher than that in control group(13\^8%,7\^3%).The difference was also significant(P<0\^05).Conclusion Xinjiang Uighur and Han women’s cervical erosion is associated with the infection of HSV 2.更多还原