【摘要】 目的　探讨加用膳食纤维的肠内营养对促进短肠大鼠结肠的代偿作用。　方法　将2 0只短肠大鼠随机分 2组 ,口服Pepti 2 0 0 0组 (EN)组及加用膳食纤维 (EF)组 ,并以正常鼠为对照(CONT)组。观察全身营养状况和结肠形态改变。　结果　术后 15天EF组体重增加 ,并于第 18天起明显优于EN组 (P <0 .0 5 ) ;第 9天EN组正氮平衡明显低于CONT组 (P <0 .0 0 1) ,而EF组与CONT组无差别。结肠壁厚度、粘膜厚度、绒毛高度和绒毛表面积 ,EF组与EN组及CONT组相比差异有非常显著性意义 (P <0 .0 1)。结肠粘膜细胞DNA指数 ,EN和EF组均明显高于CONT组 (P <0 .0 5 ) ,且S期细胞百分比均明显高于CONT组 (P <0 .0 5 )。各实验组IGF lmRNA含量与CONT组相比差别有非常显著性意义 (P <0 .0 1)。　结论　加膳食纤维治疗的短肠大鼠全身营养状况及结肠代偿明显优于单用肠内营养组。更多还原

【Abstract】 Objective To study the colonic adaptation of short bowel rats by enteral nutrition plus fiber treatment. Methods The short bowel rats were randomized into two groups:feed by Pepti-2000(EN)and by Pepti-2000 plus fiber(EF);and another normal rats as control(CONT)group.The nutritional states and morphologic changes of the colon were investigated. Results From postoperative days (PODs)15,the weight of EF group was increasing and greater than EN group after PODs 18.The net nitrogen balance in EF group was almost the same as CONT,but greater than EN group.All the mucosal thickness,villous height and surface area of the colon in EF group were greater than CONT and EN group (P< 0.001).DNA content and hydipoloid cells of the colonic mucous in study groups was higher than CONT group(P< 0.05).Also the levels of colonic mucous IGF-1 mRNA in study groups was higher than CONT group (P< 0.05). Conclusions Enteral nutrition plus fiber can not only promote nutritional states;but enhance colonic adaptation to the short bowel rats.更多还原