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桂竹糖芥苷G对肾小管功能及髓袢升支粗段70-pS钾通道活性的影响(英文)

Effects of erysimin G on renal tubular function and 70-pS K ~+ channel activity of thick ascending limb

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【作者】 单宏丽张晓丹谷瑞民罗大力杨宝峰

【Author】 SHAN Hong-Li, ZHANG Xiao-Dan, GU Rui-Min, LUO Da-Li, YANG Bao-Feng(Department of Pharmacology, Department of Physiology, Harbin Medical University, Harbin 150086, China;Department of Pharmaceutics, Heilongjiang Commmercial College, Harbin 150076, China)

【机构】 哈尔滨医科大学药理教研室黑龙江省商学院哈尔滨医科大学生理教研室哈尔滨医科大学药理教研室 哈尔滨中国 150086哈尔滨 中国 150076哈尔滨中国 150086

【摘要】 目的:研究桂竹糖芥苷G(erysimine G)的利尿作用及其作用机制。方法:应用尿道插管观察给药前后尿量变化;并应用膜片箝技术记录大鼠肾脏髓袢升支粗段70-pS钾通道的活性改变。结果:给予桂竹糖芥苷G后,实验动物尿量显著增加。单通道实验记录表明:应用桂竹糖芥苷G1μmol·L-1抑制TAL70-pS钾通道的活性,NPo由正常对照的1.67±0.10降低至0.05±0.02(P<0.01,n=4)。结论:桂竹糖芥苷G有明显的利尿作用,其利尿机制可能与抑制TAL单细胞70-pS钾通道的活性有关。

【Abstract】 AIM: To study the effect of erysimin G (CH35H52O13 on the thick ascending limb (TAL) 70-pS K+ channel of rat kidney and its effect on diuresis. METHODS: The patch-clamp cell-attached recording technique was used to record the single potassium channel current, and the urine volume (UV) was measured by urethal intubation to determine the diuretic effect. RESULTS: Erysimin G can increase the urine volume and decrease the 70-pS potassium channel activity of TAL. CONCLUSION: Erysimin G has a diuretic effect and its inhibition on the activity of apical 70-pS potassium channel may be the mechanism of its diuretic effect.

【基金】 Project supported by the National Natural Science Foundation of China,No 30070925
  • 【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,2001年05期
  • 【分类号】R285
  • 【下载频次】78
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