【摘要】 目的:观察胍丁胺对颈动脉窦压力感受器反射的影响。方法:利用灌流左颈动脉窦方法,观察胍丁胺对麻醉大鼠压力反射机能参数的影响。结果:（1）胍丁胺1,5,10mmol/L均使颈动脉窦压力反射机能曲线向右上方移位,曲线最大斜率和反射性平均动脉压下降幅度均减小,提示胍丁胺对压力感受器反射有抑制作用;（2）预先应用咪唑啉受体（IR）和肾上腺素能α₂受体（α₂-AR）拮抗剂咪唑克生（idazox-an,0.1mmol/L）,则可完全阻断胍丁胺5mmol/L的效应。预先应用α₂受体拮抗剂育亨宾（yohimbine,15μmol/L）,则可部分阻断其效应;（3）预先应用NOS抑制剂L-NAME（500μmol/L）,对胍丁胺的抑制作用无影响。结论:胍丁胺对颈动脉窦压力反射有抑制作用,并由咪唑啉受体和α₂受体介导。更多还原

【Abstract】 AIM: To study the effect of agmatine (Agin) on carotid sinus baroreflex. METHODS: The functional parameters of baroreflex were measured by perfusing the carotid sinus in anesthetized rats. RESULTS: (1) Agm 1,5, and 10 mmol/L shifted the functional curve of carotid sinus baroreflex to the right and upwards in a concentration-dependent manner with a reduction in peak slope and a reflex decrease in mean arterial pressure, indicating that Agm exerted an inhibitory effect on the carotid baroreflex. (2) The inhibitory effect of Agm (5 mmol/L) on baroreflex was eliminated by pretreatment with idazoxan (Ida, 0.1 mmol/L), an α2-adrenoceptor (α2-AR) and imidazoline receptor (IR) antagonist, and partially blocked by yohimbine (Yoh, 15 μmol/L), a selective α2-AR antagonist. (3) NG-nitro-L-arginine methyl ester (Z--NAME, 500 μmol/L), an NOS inhibitor, did not affect the inhibitory effect of Agm. CONCLUSION: Agm inhibits carotid baroreflex via IR and α2-AR.更多还原