【摘要】 为了观察用国产重组酵母乙型肝炎 (乙肝 )疫苗 ,对已经血源乙肝疫苗初免的儿童再免疫的效果 ,以乙肝表面抗原 (HBsAg)和乙肝e抗原 (HBeAg)阴性母亲所生的、出生时全程接种血源乙肝疫苗后已 4年的儿童为对象 ,用5 μg重组酵母乙肝疫苗进行再免疫 ,同时用 10 μg血源乙肝疫苗再免疫作对照 ,观察 2种疫苗再免疫后 1、12、2 4个月乙肝表面抗体 (抗 -HBs)反应。结果显示 :用 5 μg重组酵母乙肝疫苗进行再免疫能取得良好的抗 -HBs应答 ,不论再免疫前抗 -HBs水平高低 ,再免疫后能呈现免疫回忆反应。再免疫的抗体反应模式与用 10 μg血源乙肝疫苗进行再免疫的相似。两种乙肝疫苗再免疫的效果无显著性差异。因此 ,用 5 μg重组酵母乙肝疫苗与 10 μg血源乙肝疫苗再免疫能获得相同的再免疫效果。更多还原

【Abstract】 This paper was to observe the revaccination effect of domestic yeast-derived recombinant hepatitis B vaccine (YRHBV) to children who were born to HBsAg and HBeAg negative mothers and had been immunized with full course of blood-derived hepatitis B vaccine 4 years ago at their birth. The treated group was revaccinated with 5μg YRHBV while the control group with 10μg blood-derived HB vaccine, their anti-HBs response was determined 1,12,24 months after revaccination. The results showed that a nice anti-HBs response was discovered in group A childeren, no matter how about the anti-HBs level before revaccination was. The kinetics of anti-HBs after YDHBV revaccination was similar to that of the blood-derived HB vaccine, no statistical difference was found. So, 5μg of domestic yeast-derived recombinant HB vaccine gave same immune effect as well as 10μg blood-derived HB vaccine.更多还原