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用国产重组酵母乙型肝炎疫苗进行再免疫的效果观察

The Revaccination Effect of Domestic Yeast-derived Recombinant Hepatitis B Vaccine

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【作者】 王振海朱顺元吴祖云

【Author】 WANG Zhen hai, ZHU Shun yuan, WU Zu yun Jiaxing Epidemic Prevention Station, Zhejiang, Jiaxing 314001, China.

【机构】 嘉兴市卫生防疫站!浙江嘉兴314001

【摘要】 为了观察用国产重组酵母乙型肝炎 (乙肝 )疫苗 ,对已经血源乙肝疫苗初免的儿童再免疫的效果 ,以乙肝表面抗原 (HBsAg)和乙肝e抗原 (HBeAg)阴性母亲所生的、出生时全程接种血源乙肝疫苗后已 4年的儿童为对象 ,用5 μg重组酵母乙肝疫苗进行再免疫 ,同时用 10 μg血源乙肝疫苗再免疫作对照 ,观察 2种疫苗再免疫后 1、12、2 4个月乙肝表面抗体 (抗 -HBs)反应。结果显示 :用 5 μg重组酵母乙肝疫苗进行再免疫能取得良好的抗 -HBs应答 ,不论再免疫前抗 -HBs水平高低 ,再免疫后能呈现免疫回忆反应。再免疫的抗体反应模式与用 10 μg血源乙肝疫苗进行再免疫的相似。两种乙肝疫苗再免疫的效果无显著性差异。因此 ,用 5 μg重组酵母乙肝疫苗与 10 μg血源乙肝疫苗再免疫能获得相同的再免疫效果。

【Abstract】 This paper was to observe the revaccination effect of domestic yeast-derived recombinant hepatitis B vaccine (YRHBV) to children who were born to HBsAg and HBeAg negative mothers and had been immunized with full course of blood-derived hepatitis B vaccine 4 years ago at their birth. The treated group was revaccinated with 5μg YRHBV while the control group with 10μg blood-derived HB vaccine, their anti-HBs response was determined 1,12,24 months after revaccination. The results showed that a nice anti-HBs response was discovered in group A childeren, no matter how about the anti-HBs level before revaccination was. The kinetics of anti-HBs after YDHBV revaccination was similar to that of the blood-derived HB vaccine, no statistical difference was found. So, 5μg of domestic yeast-derived recombinant HB vaccine gave same immune effect as well as 10μg blood-derived HB vaccine.

  • 【文献出处】 中国计划免疫 ,Chinese Journal of Vaccines and Immunization , 编辑部邮箱 ,2001年02期
  • 【分类号】R186
  • 【被引频次】2
  • 【下载频次】26
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