【摘要】 为考核并比较甲型肝炎减毒活疫苗 (甲肝疫苗 )的免疫学效果 ,对 314名易感儿童随机分为 3组 ,分别接种市售昆明、杭州、长春 3个厂家生产的甲肝疫苗 ,免疫后 2 1、34天采血检测抗 -HAV。结果显示 :免疫后 2 1天 3个厂家甲肝疫苗抗 -HAV阳转率分别为 6 1 9%、6 0 9%和 80 0 % ,免疫后 34天分别为 71 6 %、6 6 7%和 44 9% ,国产高滴度甲肝疫苗安全性好 ,但疫苗质量有待进一步提高 ,以获得更好的免疫学效果更多还原

【Abstract】 To evaluate and compare the immune effects of three kinds of domestic live attenuated hepatits A vaccines, 314 anti hepatitis A virus(HAV)antibody negative children were randomly divided into 3 groups and vaccinated with commercial live attenuated hepatitis A vaccines made in Kunming, Hangzhou and Changchun respectively. Serum samples collected 21 and 34 days after inoculation were tested for anti HAV. The vaccines produced in 3 factories all had a similar positive seroconversion rates of 61.9%, 60.9% and 80.0% 21 days after, vaccination and a significantly differential rates of 71.6%, 66.7% and 44.9% 34 days after. The results suggested that China made live attenuated hepatits A vaccine with higher titer is safe, but the quality need to be improved to get a better immune efficacy.更多还原