【摘要】 目的　探讨中年人群血清尿酸 (SUA)与四年后血压变化及高血压 (HYP)发病的关系。方法　在 1984年基线调查的 35～ 5 9岁血压正常 (低于 135 / 85mmHg)、有SUA值的 16 5 6名男女中 ,1988年有 1480人 (男性 6 0 9,女性 871)参加了复查 ,以此为队列人群 ,观察高血压的发病率及血压变化。结果　随防四年高血压发病率为 13.1%。无论男女 ,按尿酸四分位分析显示高血压发病率随分位数增加而升高。多元Logistic回归分析 ,当控制年龄后在男性SUA增加 1个标准差 (1.14mg/dl)是显著地增加HYP发病危险 (HYP发病相对危险RR =1.40 ,95 %可信限 1.12～ 1.74)。当BMI、吸烟、饮酒和基线SBP加入模型 ,SUA与HYP发病的关系减弱但仍有统计学显著性 (RR =1.2 8,95 %可信限1.0 1～ 1.6 1)。多元线性回归分析 ,在男性基线年龄、SUA、BMI、和体重变化与 4年的SBP变化呈正的显著关联。在女性SUA与高血压发病及血压变化均无显著关联。结论　结果表明在男性SUA对血压升高及高血压发病是个独立于体重指数 (BMI)、吸烟和饮酒的危险因素。更多还原

【Abstract】 Objective\ To assess the relationships of baseline serum uric acid (SUA) to 4\|year risk of developing high blood pressure (HYP) and to 4\|year change in blood pressure in a middle aged population. \ Methods\ 1656 participants aged 35～59 men and women at baseline survey in 1984 were non\|hypertensive (<135/85mmHg) were registered. In 1988 1,480 (609 men, 871 women) were reexamined. Hypertension incidence of the cohort was calculated. Logistic regression and multiple linear regression model were used. \ Results\ HYP incidence (SBP>=140 or DBP>=90 or using antihypertensive drugs in the last two weeks) was 13.1% (men:15.1%; women:11.7%). For both genders, HYP incidence was higher with higher SUA quartile (\%P\%<0 05). In 1984, there were significant positive correlations of SUA with DBP and BMI (both genders), with SBP and age (women only), and in 1988 with SBP, DBP, and BMI (both genders). Multiple logistic regression analyses showed baseline SUA and age was the risk factor for developing hypertension. An increase of 1SD(1.14 mg/dl) in SUA was associated with significantly greater risk of HYP for men (OR 1.40, 95% CI: 1.12～1.74). After adjustment of BMI, alcohol, smoking, and baseline SBP, this SUA\|HPY relationship in male was attenuated but remained statistically significant (OR=1.28, 95% CI=1.01～1.61). Multiple linear regression analyses showes baseline age, SUA, BMI, and change of body weight were significantly positively related to 4\|year change in SBP for men. For women, no significant relation was found between SUA and HYP incidence as well as the change in SBP.\ Conclusion\ These data indicate that SUA is a risk factor for HYP incidence in male, that is independent of BMI, smoking, and alcohol intake.更多还原